Lately I noticed I started stress-eating a lot, and this probiotic really helped. I feel calmer, less anxious, and my cravings aren’t all over the place. Definitely part of my daily routine now.
Anti-Stress Probiotics
Struggling to sleep because you’re stressed and unable to relax because you’re exhausted?
Here’s How to Break the Sleep–Stress Cycle
- Fall asleep in 20 minutes, not hours*
- Wake up actually rested*
- Quiet racing thoughts*
- Take back control of your nights*
- 100% Money-Back Guarantee
- Free Shipping
- Cancel Anytime
Delayed-Release Capsules
Third-Party Tested
FDA & GMP
Vegan
Non-GMO
Gluten-Free
Manufactured in USA
BENEFITS OF OUR INGREDIENTS ARE RESEARCHED BY
Choose Your BIOMA Probiotics Package And Restore Your Gut-Brain Connection
Free Shipping On All Orders
Cancel Anytime
100% Money-Back Guarantee
Try It Out SAVE 40%
1-Month Supply
Perfect for trying out
$53.99per bottle
$89.99
- 30 servings ($1.79/day)
- Perfect for trying out
- 1 bottle delivered
Try It Out Save 20%
1-Month Supply
Perfect for trying out
$71.99per bottle
$89.99
- 30 servings ($2.39/day)
- Perfect for trying out
- 1 bottle delivered
Most Popular SAVE 45%
3-Month Supply
Build healthy habits
$49.49per bottle
$89.99
- 90 servings ($1.64/day)
- Build healthy habits
- 3 bottles delivered
Most Popular Save 30%
3-Month Supply
Build healthy habits
$62.99per bottle
$89.99
- 90 servings ($2.09/day)
- Build healthy habits
- 3 bottles delivered
Best Value SAVE 50%
6-Month Supply
Full Anti-Stress cycle
$44.99per bottle
$89.99
- 180 servings ($1.49/day)
- Full Anti-Stress cycle
- 6 bottles delivered
Best Value Save 35%
6-Month Supply
Full Anti-Stress cycle
$58.49per bottle
$89.99
- 180 servings ($1.94/day)
- Full Anti-Stress cycle
- 6 bottles delivered
Plans renews automatically till cancelled
Third-Party Tested
Secure Checkout-
Gluten-Free | Vegan
Organic Mushrooms
Manufactured in USA
100% Natural & Non-GMO
FDA & GMP Certified Facilities
Dark Glass Bottles for Product Quality
Delayed-Release Capsules
Join 35,000+ BIOMA Probiotics Customers Who Went From Sleepless & Stressed To Rested & Restored
The biggest change has been sleep. I don't toss and turn the same way anymore. I actually wake up rested. That alone makes BIOMA worth it.
I used to lie awake for hours with racing thoughts. After 3 weeks on BIOMA Probiotics, I fall asleep naturally and stay asleep. Game changer.
My stress was destroying my sleep and my sleep was making me more stressed. BIOMA Anti-Stress Probiotics finally broke that cycle. I feel like myself again.
- 100% Money-Back Guarantee
- Free Shipping
- Cancel Anytime
Why You Can't Sleep No Matter How Exhausted You Are, And Why It's Getting Worse
If you struggle to fall asleep, wake up multiple times per night, or feel exhausted even after 7-8 hours in bed, the problem isn't your mattress or your bedtime routine.
This is your body's communication superhighway for sleep signals.
And here's what most people don't know: 95% of your body's serotonin, the precursor to melatonin (your sleep hormone), is produced in your gut, not your brain[1][5].
It's your damaged gut-brain connection.
Your gut and brain are directly connected through the vagus nerve[4].This is your body's communication superhighway for sleep signals.
And here's what most people don't know: 95% of your body's serotonin, the precursor to melatonin (your sleep hormone), is produced in your gut, not your brain[1][5].
When your gut-brain connection is healthy:
- Gut bacteria influences serotonin and GABA production, affecting sleep-wake signaling
- Your vagus nerve transmits "time to sleep" signals efficiently[4]
- Cortisol naturally drops in the evening so you feel drowsy[2]
- You fall asleep easily and stay asleep through the night
- You wake up feeling genuinely rested and restored
But here's where things go wrong…
When chronic stress hits day after day, it damages this entire system.
Stress elevates cortisol[2], which directly suppresses melatonin production[6]. But worse, chronic stress also kills off the exact gut bacteria that produce the calming neurotransmitters GABA and serotonin[4][7].
You can think of your vagus nerve as your "sleep superhighway," but if it's inflamed and blocked by chronic stress, even though your gut is trying to send sleep signals, your brain never gets the message[4].
Your gut produces 95% of serotonin[1]
Healthy gut bacteria promote serotonin production, which supports your body's sleep-wake signaling[8][9].
Chronic stress destroys sleep signals
Stress elevates cortisol, kills GABA-producing bacteria, and blocks vagus nerve signaling[2][4][7].
This creates the Sleep-Stress Cycle
Poor sleep → more cortisol → worse sleep → more stress → the cycle feeds itself[2][3].
So here’s the real problem.
70 Million Americans Have A Sleep Disorder, And Stress Is A Leading Cause[10][11]
The relationship between stress and sleep is bidirectional. Meaning stress causes poor sleep AND poor sleep causes more stress[2]. This creates a self-perpetuating trap that gets worse over time.
This creates what we call "The Sleep-Stress Cycle"
…and the cycle repeats.
You're trapped in the Sleep-Stress Cycle where poor sleep causes more stress and more stress destroys your sleep.
Sleep deprivation causes your body to produce significantly more cortisol during the day.[13]
Studies show that even one night of poor sleep elevates cortisol levels and makes you more reactive to stress.[14]
This creates the vicious cycle: stress → poor sleep → higher cortisol → more stress → worse sleep.[2]
Each bad night makes the next one more likely.
Studies show that even one night of poor sleep elevates cortisol levels and makes you more reactive to stress.[14]
This creates the vicious cycle: stress → poor sleep → higher cortisol → more stress → worse sleep.[2]
Each bad night makes the next one more likely.
Cortisol naturally begins rising around 3-4AM to prepare you for waking[12].
But when your stress system is dysregulated from chronic stress, this cortisol surge happens too strongly and too early[2], jolting you awake.
Your gut bacteria that produce GABA (your brain's "calm down" signal) are likely depleted, so there's nothing to counteract this cortisol spike and help you fall back asleep.[7][4]
But when your stress system is dysregulated from chronic stress, this cortisol surge happens too strongly and too early[2], jolting you awake.
Your gut bacteria that produce GABA (your brain's "calm down" signal) are likely depleted, so there's nothing to counteract this cortisol spike and help you fall back asleep.[7][4]
95% of your body's serotonin is produced in your gut[1].
Your gut's serotonin production influences your body's overall sleep-wake regulation[9].
Specific gut bacteria (like Lactobacillus and Bifidobacterium) produce GABA, the neurotransmitter that calms your nervous system for sleep.[7]
When these bacteria are depleted by chronic stress[4], your gut literally cannot produce the signals your brain needs to sleep.
Your gut's serotonin production influences your body's overall sleep-wake regulation[9].
Specific gut bacteria (like Lactobacillus and Bifidobacterium) produce GABA, the neurotransmitter that calms your nervous system for sleep.[7]
When these bacteria are depleted by chronic stress[4], your gut literally cannot produce the signals your brain needs to sleep.
Melatonin supplements only add the end-product.
They don't fix why your body stopped producing melatonin naturally.
If your gut bacteria are depleted[4] and your vagus nerve is inhibited from chronic stress[4], supplementing melatonin is like putting a bandaid on a broken pipe.
You need to restore the entire gut-brain sleep system, not just add more of one hormone.
They don't fix why your body stopped producing melatonin naturally.
If your gut bacteria are depleted[4] and your vagus nerve is inhibited from chronic stress[4], supplementing melatonin is like putting a bandaid on a broken pipe.
You need to restore the entire gut-brain sleep system, not just add more of one hormone.
Now you know the real problem. So why don’t the usual solutions work?
Why Melatonin, Sleep Apps & Prescription Sleep Aids Keep Failing You
If you've tried everything with no lasting results… It’s not your fault.
Here's why...
Adding melatonin doesn't fix WHY your body stopped producing it.
WHAT THEY SAY:
"Just take melatonin and you'll sleep like a baby."
THE REALITY:
Melatonin supplements bypass your gut's natural production.
They don't restore the gut bacteria that support your body's natural sleep signaling.
That's why melatonin often stops working, it doesn't address the underlying dysfunction.
They force sleep but don't restore natural sleep architecture or address stress.
WHAT THEY SAY:
“This will knock you out so you can finally sleep."
THE REALITY:
Sleep medications suppress your nervous system artificially[15].
They don't produce natural, restorative sleep stages[15].
You might be unconscious longer, but you're not getting the deep, restorative sleep your body needs.
Plus, they can create dependency[15] and don't touch your underlying stress.
Good habits help, but they can't overcome broken gut-brain chemistry.
WHAT THEY SAY:
"Just put away your phone, cool your room, and follow these 10 tips."
THE REALITY:
Sleep hygiene matters, but it can't manufacture GABA and serotonin that your depleted gut bacteria aren't producing.
It can't lower cortisol when your HPA axis is dysregulated.
You can have perfect sleep hygiene and still lie awake for hours because your gut-brain connection is broken.
95% die in stomach acid[16], and most don't contain the specific strains that produce sleep-promoting neurotransmitters.
WHAT THEY SAY:
"Probiotics support overall health including sleep."
THE REALITY:
Most probiotics die in stomach acid before reaching your gut[16].
Even survivors rarely contain the clinically-proven strains that actually produce GABA and support vagus nerve function.
BIOMA Anti-Stress Probiotics uses delayed-release capsules and specific strains proven to produce GABA and improve sleep[16][17][18].
And none of these address the root cause:
Restoring Your Gut-Brain Sleep Connection
Not restoring your gut-brain connection means your body stays trapped in the Sleep-Stress Cycle. Your cortisol stays elevated.
Your gut can't produce GABA and serotonin. Your vagus nerve stays inhibited. Every night becomes a battle, and every morning starts already exhausted.
Your gut can't produce GABA and serotonin. Your vagus nerve stays inhibited. Every night becomes a battle, and every morning starts already exhausted.
Without A Restored Gut-Brain Connection
- Cortisol elevated at night
- GABA-producing bacteria depleted
- Vagus nerve inhibited and blocked
- Melatonin suppressed
- Trapped in the Sleep-Stress Cycle
With Your Gut-Brain Connection Restored
- Cortisol naturally drops for sleep
- GABA being produced to calm your mind
- Sleep signals flowing freely
- Natural melatonin production restored
- Cycle broken, restful sleep restored
So if traditional solutions don’t work… what does?
You need to restore your gut-brain sleep connection first.
Introducing The Revolutionary 3-in-1 Anti-Stress Formula That Breaks The Sleep-Stress Cycle
Unlike traditional sleep aids, BIOMA Anti-Stress Probiotics targets the vagus nerve and gut-brain axis directly with clinically-proven strains that produce GABA[17] and restore your body's natural sleep signals.
Traditional Approach
- Targets only symptoms
- Temporary effects (one night)
- Single mechanism
- Ignores gut-brain connection
- Can create dependency
- Doesn't address stress
Bioma's Approach
- Addresses root cause
- Lasting transformation
- 3-in-1 synergistic system
- Restores gut-brain sleep pathway
- Supports natural sleep production
- Breaks the Sleep-Stress Cycle
Most sleep supplements try to force sleep artificially. But it's like trying to start a car by pushing it downhill, you might move, but the engine is still broken.
BIOMA Anti-Stress Probiotics works differently.
Once your gut barrier is sealed[19], sleep signals can flow properly again.
That's why BIOMA includes three clinically-proven probiotic strains that produce GABA and support the vagus nerve[4], protected by delayed-release capsules so they survive stomach acid[16], and fed by prebiotic fiber to keep them working[20], all working in sequence to break the Sleep-Stress Cycle at its root.
Step 1
Repair The Sleep Signal Pathway
TriBiom™ Tributyrin (350mg)
POSTBIOTIC
What Is It:
The world's only fermented tributyrin that releases butyrate directly to your colon to seal your gut barrier and reduce inflammation[19].
Why it Matters:
Research shows tributyrin increases non-REM sleep (deep, restorative sleep) by almost 50%[21]. It strengthens tight junctions, reduces inflammation[19], and clears the pathway so sleep signals can reach your brain. Your vagus nerve can finally communicate properly.
The Result:
Your gut-brain sleep connection begins healing from the ground up.
Step 2
Restore The Sleep Neurotransmitter Producers
Vagus Nerve Probiotic Blend (12 Billion CFU)
Probiotics
What Is It:
Lactobacillus plantarum (Lp815), Lactobacillus rhamnosus (HN001), and Bifidobacterium longum (BI-05)—three clinically-proven strains shown to produce GABA, reduce stress, and improve sleep quality.
Why it Matters:
- Lp815 produces GABA and significantly reduces insomnia severity scores within 4-6 weeks. Clinical trials show increased total sleep duration and deep sleep [22].
- HN001 reduces anxiety and depression symptoms that interfere with sleep[23].
- BI-05 supports gut-brain balance and emotional well-being.
The Result:
Your gut restarts producing GABA and serotonin. the neurotransmitters that calm your mind and signal sleep.
Step 3
Fuel Ongoing Sleep Signal Production
Chicory Root Inulin (250mg)
Prebiotic
What Is It:
Prebiotic fiber that feeds beneficial bacteria like our three clinically-proven sleep-supporting strains: Lp815, HN001, and BI-05.
Why it Matters:
Research shows prebiotics enhance NREM sleep (deep sleep) and promote faster sleep recovery after stress[24]. Without prebiotics, probiotics die in 2-3 weeks and your sleep benefits fade[20].
The Result:
Your gut continuously produces GABA and sleep signals night after night.
- 100% Money-Back Guarantee
- Free Shipping
- Cancel Anytime
What Happens When You Restore Your Gut-Brain Sleep Connection
Here’s exactly what to expect when you start Bioma Anti-Stress Probiotics
Initial Relief
Days 1-5
What’s happening: Gut barrier repair begins, inflammation decreases, vagus nerve signaling starts improving.
What you'll notice:
- Slight decrease in racing thoughts at bedtime*
- May fall asleep slightly faster*
- First signs of waking up less groggy*
Sleep Signals Restoring
Weeks 1-2
What’s happening: Beneficial bacteria multiply, GABA production increases, cortisol begins normalizing.
What you'll notice:
- Noticeably easier time falling asleep*
- Fewer middle-of-the-night wake-ups*
- Waking up more rested*
- Less anxious as bedtime approaches*
The Cycle Breaks
Months 1-2
What’s happening: Gut barrier fully repaired, sleep neurotransmitter production optimized, Sleep-Stress Cycle weakening.
What you'll notice:
- Falling asleep within 20-30 minutes consistently*
- Sleeping through the night*
- Deep, restorative sleep becoming normal*
- Morning energy you haven't felt in years*
- Stress feels more manageable*
Sleep Becomes Natural
Months 3-4
What’s happening: What's happening: Microbiome diversity peaks, vagus nerve fully restored, natural circadian rhythm returning.
What you'll notice:
- Sleep feels effortless, you just drift off*
- 7-8 hours of quality sleep consistently*
- Waking up before your alarm, feeling refreshed*
- Calm, stable mood throughout the day*
- Friends notice you seem more rested and relaxed*
Freedom From The Cycle
Months 5-6+
What’s happening: Self-sustaining microbiome, lasting gut-brain connection, complete circadian rhythm restoration.
What you'll notice:
- Sleep is no longer something you "work at"*
- Natural drowsiness at bedtime, natural energy at wake time*
- Stress no longer destroys your sleep*
- Total freedom from the Sleep-Stress Cycle*
- Feel like a completely different person*
Why 6 Months Is The Perfect Timeline For Complete Sleep-Stress Cycle Break
The science is clear. Restoring gut-brain health and breaking the Sleep-Stress Cycle requires time and consistency.
Clinical trials show that while you notice initial sleep improvements in 2-4 weeks, maximum benefits for insomnia severity, sleep duration, and deep sleep occur at 4-6 weeks[22], with continued improvement building through month 3 and beyond.
Months 1-2
Break The Cycle
Months 3-4
Restore Natural Sleep
Months 5-6
Lock In The Transformation
"After 6 months on BIOMA Anti-Stress Probiotics, I sleep like I did in my 20s. No racing thoughts. No 3AM wake-ups. Just deep, restful sleep every night. I finally feel like myself again."
Choose Your BIOMA Probiotics Package And Break Free From The Sleep-Stress Cycle
Free Shipping On All Orders
Cancel Anytime
100% Money-Back Guarantee
Try It Out SAVE 40%
1-Month supply
Perfect for trying out
$53.99per bottle
$89.99
- 30 servings ($1.79/day)
- See initial results in 2 weeks
- 1 bottle delivered
Try It Out Save 20%
1-Month supply
Perfect for trying out
$71.99per bottle
$89.99
- 30 servings ($2.39/day)
- See initial results in 2 weeks
- 1 bottle delivered
Most Popular SAVE 45%
3-Month supply
Build stress resilience
$49.49per bottle
$89.99
- 90 servings ($1.64/day)
- Build healthy habits
- 3 bottles delivered
Most Popular Save 30%
3-Month supply
Build stress resilience
$62.99per bottle
$89.99
- 90 servings ($2.09/day)
- Build healthy habits
- 3 bottles delivered
Best Value SAVE 50%
6-Month supply
Lasting Stress Protection
$44.99per bottle
$89.99
- 180 servings ($1.49/day)
- Full Anti- Stress cycle
- 6 bottles delivered
Best Value Save 35%
6-Month supply
Lasting Stress Protection
$58.49per bottle
$89.99
- 180 servings ($1.94/day)
- Full Anti- Stress cycle
- 6 bottles delivered
Plans renews automatically till cancelled
Third-Party Tested
Secure Checkout
Gluten-Free | Vegan
Organic Mushrooms
Manufactured in USA
100% Natural & Non-GMO
FDA & GMP Certified Facilities
Dark Glass Bottles for Product Quality
Delayed-Release Capsules
100% Money-Back Guarantee
We're so confident BIOMA Anti-Stress Probiotics will help you fall asleep faster, sleep deeper, and wake up rested that we offer a complete money-back guarantee.
If you don't notice improvements within 14 days: falling asleep easier, sleeping through the night, or waking up more rested, simply contact us for a full refund.
100% Money-Back Guarantee
Free Shipping
Cancel Anytime
Our Customers Talk About Bioma
Customer Reviews
Overall rating: 4.5 / 5 from 384 reviews.
Work stress had been getting to me, so I tried these anti-stress probiotics. They’ve made such a difference. Feeling calmer and more balanced even on busy days…
After about a month I realized I wasn’t snapping at the little things anymore
This helped take the edge off my stress and also reduced my emotional eating. I feel more in control and steady.
my job didn’t magically get easier. But since taking Bioma, I feel like I can roll with it more :)
THANK YOU BIOMA! I’ve been taking this religiously for 3 months now, my stomach feels calmer and, weirdly, so do I!
Anxiety has always shown up in my stomach, like on nights before big events, first dates, etc. Now I get way fewer symptoms like this, so I’m happy.
A few days in and I feel calmer, clearer, and more grounded
I feel like myself again
Good product. Bloating is better, mood is steadier too
It took about a month before I noticed a big difference, but now I feel so much calmer
My stomach used to feel like a knot… I wasn’t expecting much, honestly. But I noticed I wasn’t tossing and turning as much at night… that’s enough for me to keep taking it
I don’t feel ‘cured’ or anything, but I do feel calmer and more steady. I don’t overreact to little things the way I used to, and that makes home life a lot easier. My wife noticed before I did, which says a lot.
I never leave reviews, but Bioma deserves it. My life is stressful and I used to feel like I was always on edge. Now I feel like my body has more room to handle it xx
The biggest change for me has been sleep. I don’t toss and turn the same way anymore… I actually wake up rested. That alone makes it worth it…
wasn’t sure if it was doing anything, then I skipped a week, that’s when I realized how much it helped!!
I’m just getting started, haven’t finished my first bottle yet.
I like that there are strains that work well with the nervous system.
It has really helped the problems with my stomach. I would. I would advise it for anybody if they have the stomach problems like I have.
Haven’t seen any difference. Ben on for 60+ days.
I don’t feel any different than before.
Don't waste your money for this product does not work.
My naturopath recommended something. Different....
It just wasn’t for me it was making me agitated after 5 days of taking them so I stopped. I also want to stop the subscription. Thank you.
Only been taking it a few days, but I think it’s making a difference in my day to day random feelings of anxiety!
Quite frankly I haven’t noticed any improvement in my symptoms. I may not continue with it once I’ve finished the second bottle unless there’s a change.
My gastroenterologist told me not to take because of my gut problems and they returned my money ASAP !!
Seems to help, so I'm sticking with it for awhile!
So far working well for me
Haven't taken it long enough yet.
so far so good
Helps me feel calm, not having such a jittery in my gut. I take it every morning and I feel good.
Too early to tell
I dont know if this works yet, but I decided to give it 2 months. I finished month 1. I have a pretty extreme anxiety disorder and I figured this couldn't hurt to try. There haven't been any negative side effects. It could be doing something, but I take a lot of supplements so there's no telling whats moving the needle.
So far I have had no relief from taking the Anti-Stress Probiotics.
I've only been taking it for about 4 days and I've noticed a difference in my anxiety already! It's not completely gone, but each day gets better and better! It's the only thing that's helped in 4 years. This is not a joke or AI generated...coming from a real person!
Too early to tell, but optimistic!
I guess it’s works I think it helps my stress some but not been a full month yet not sure outside how I feel knowing it works or does not I do take other things but still will to try it. Trial by error seems like this stage of my life. Still have 2 more than a half bottle to go.
Amazing product
I haven’t noticed much difference yet
What’s Inside Bioma’s Anti-Stress Probiotics
Highest Standards of Quality, Powerhouse Ingredients, All Backed By Science
Manufacturing Excellence
- FDA & GMP Facilities
- Delayed-Release Capsules
- Pharma-Grade Quality
- Strict Quality Controls
Quality Testing
- Third-Party Lab Tested
- Certificate of Analysis
- Purity & Potency Verified
- Stability Guaranteed
Clean Formula
- 100% Vegan & Non-GMO
- Gluten & Allergen Free
- No Artificial Additives
- No Fillers or Preservatives
- 100% Money-Back Guarantee
- Free Shipping
- Cancel Anytime
Imagine Waking Up Tomorrow Feeling Rested, Calm, and Ready For The Day
This could be your new reality in just a few weeks
No more..
- Lying awake for hours with racing thoughts
- Waking up at 3AM unable to fall back asleep
- Feeling exhausted even after 8 hours in bed
- Dreading bedtime because you know you won't sleep
- Morning anxiety before your eyes even open
- Needing coffee just to function
- Stress destroying your sleep, poor sleep amplifying stress
- Depending on sleep aids that stop working
- Brain fog and irritability from exhaustion
- Feeling trapped in your own body
With Bioma ANTI-STRESS Probiotics
Instead, you'll experience...
- Drifting off naturally within 20-30 minutes*
- Waking up genuinely rested and refreshed*
- Looking forward to restful, restorative nights*
- Waking up calm, clear, and ready for the day*
- Natural energy that lasts all day*
- The Sleep-Stress Cycle finally broken*
- Your body producing its own sleep signals naturally*
- Mental clarity and emotional stability*
- Confidence and control over your nights and days*
The choice is yours. Stay trapped in the Sleep-Stress Cycle, or break free in just a few weeks.
Join thousands who've already restored their sleep with BIOMA Anti-Stress Probiotics.
- Zero Risk - 100% Satisfaction Guarantee
- Free Shipping
- Cancel Anytime
Frequently Asked Questions
Get answers to common questions about BIOMA Probiotics
Most people notice easier sleep onset and fewer wake-ups within the first 2-4 weeks as gut barrier repair begins and GABA-producing bacteria colonize. Clinical trials show maximum improvements in insomnia severity at 4-6 weeks[22].
Give it at least 4 weeks to align with clinical trial timelines. Restoring your gut-brain sleep connection is biological repair, not a quick fix like a sleeping pill.
Yes, absolutely. All three probiotic strains have been studied in clinical trials with excellent safety profiles[22][23].
Daily consistency is critical. Your gut microbiome and vagus nerve need sustained support to fully restore your natural sleep signals. Unlike sleep medications, BIOMA Probiotics doesn't create dependency, it restores your body's natural sleep production.
Yes, BIOMA Probiotics are generally safe to take alongside most supplements.
✓ If taking melatonin: You can continue melatonin while starting BIOMA. Many customers find they naturally need less melatonin after 4-6 weeks as their gut starts producing serotonin again.
✓ If taking sleep medications: BIOMA works differently than sleep aids. It restores natural sleep production. Consult your doctor before making changes to prescriptions.
✓ If taking antibiotics: Space them 2-3 hours apart (antibiotics kill bacteria). Continue BIOMA during and after antibiotic treatment to help restore your microbiome.
We offer a 14-day money-back guarantee, no questions asked.
If you don't notice improvements within 14 days, falling asleep easier, fewer wake-ups, or waking up more rested, simply contact us for a full refund.
While clinical trials show maximum benefits at 4-6 weeks[22], most people notice initial improvements in sleep quality within the first 2 weeks. If you feel absolutely no difference by day 14, we want to make it right.
We recommend taking 2 capsules once daily in the morning before breakfast with a full glass of water.
For best results:
✓ Take at the same time every day
✓ On an empty stomach allows better colonization[10]
✓ Morning timing aligns with clinical trial protocols[15]
Note: You don't need to take it at night like a sleep aid. BIOMA works by restoring your gut-brain connection, not by sedating you. Taking it in the morning gives bacteria all day to colonize and start producing GABA.
Storage: No refrigeration required. Bioma is shelf-stable at room temperature. Keep in a cool, dry place away from direct sunlight.
100% Money-Back Guarantee
Free Shipping
Cancel Anytime
References
[
1
]
Terry N, Margolis KG. Serotonergic Mechanisms Regulating the GI Tract. Handb Exp Pharmacol. 2017.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5526216/
[
2
]
Hirotsu C, Tufik S, Andersen ML. Interactions between sleep, stress, and metabolism. Sleep Sci. 2015.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4688585/
[
3
]
Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999.
https://pubmed.ncbi.nlm.nih.gov/10543671/
[
4
]
Bonaz B, et al. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5808284/
[
5
]
Peuhkuri K, et al. Dietary factors and fluctuating levels of melatonin. Food Nutr Res. 2012.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3402070/
[
6
]
Sertaridou EN, et al. Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock. Ann Intensive Care. 2018.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6279676/
[
7
]
Conn KA, et al. Implications of microbe-derived GABA in gut and brain barrier integrity. Gut Microbes. 2024.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11253888/
[
8
]
Yano JM, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015.
https://pubmed.ncbi.nlm.nih.gov/25860609
[
9
]
O'Mahony SM, et al. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2014.
https://pubmed.ncbi.nlm.nih.gov/25078296/
[
10
]
Kim EJ, Dimsdale JE. The effect of psychosocial stress on sleep: a review of polysomnographic evidence. Behav Sleep Med. 2007.
https://pubmed.ncbi.nlm.nih.gov/17937582/
[
11
]
Institute of Medicine. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. National Academies Press. 2006.
https://pubmed.ncbi.nlm.nih.gov/20669438/
[
12
]
Clow A, et al. The cortisol awakening response in context. Int Rev Neurobiol. 2010.
https://pubmed.ncbi.nlm.nih.gov/20970005
[
13
]
Leproult R, et al. Sleep loss results in an elevation of cortisol levels the next evening. Sleep. 1997.
https://pubmed.ncbi.nlm.nih.gov/9415946/
[
14
]
Wright KP, et al. Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain Behav Immun. 2015.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5401766/
[
15
]
Pagel JF, Parnes BL. Medications for the Treatment of Sleep Disorders: An Overview. Prim Care Companion J Clin Psychiatry. 2001.
https://pmc.ncbi.nlm.nih.gov/articles/PMC181172/
[
16
]
Dodoo CC, et al. Targeted delivery of probiotics to enhance gastrointestinal stability. Int J Pharm. 2017.
https://discovery.ucl.ac.uk/id/eprint/1568933/1/Gaisford_IJP%20probiotics%20R1.pdf
[
17
]
Yunes RA, et al. GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium. Anaerobe. 2016.
https://pubmed.ncbi.nlm.nih.gov/27794467/
[
18
]
Ito H, et al. Effects of probiotics on sleep parameters: A systematic review. Clin Nutr. ESPEN 2024.
https://pubmed.ncbi.nlm.nih.gov/39094854/
[
19
]
Duysburgh C, et al. Tributyrin (CoreBiome®) enhances butyrate levels and modulates gut health. Front Nutr. 2025.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1712993/full
[
20
]
Szala-Rycaj J, et al. The Influence of Inulin Supplementation on Microbiota. Nutrients. 2023.
https://pubmed.ncbi.nlm.nih.gov/37432210/
[
21
]
Szentirmai É, et al. Butyrate, a metabolite of intestinal bacteria, enhances sleep. Sci Rep. 2019.
https://pubmed.ncbi.nlm.nih.gov/31065013/
[
22
]
Grant AD, et al. Lactiplantibacillus plantarum Lp815 improves sleep and increases urinary GABA in a randomized, double-blind, placebo-controlled study of sleep disturbance. Sci Rep. 2026
https://pubmed.ncbi.nlm.nih.gov/41554764/
[
23
]
Slykerman RF, et al. Effect of Lactobacillus rhamnosus HN001 on Postpartum Symptoms. EBioMedicine. 2017.
https://pubmed.ncbi.nlm.nih.gov/28943228/
[
24
]
Thompson RS, et al. Dietary Prebiotics Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate Stress. Front Behav Neurosci. 2017.
https://pubmed.ncbi.nlm.nih.gov/28119579/
