The "CONSTIPATION TRAP"

95% of Americans Are Butyrate-Deficient and Struggle to Poop Regularly[1]

Here's How To Fix It In 2 Days[2]

As you age, your gut's butyrate production declines—it's the fuel your intestinal cells need to function.[3] Without it, you're trapped in a cycle where constipation causes more constipation.

Bioma breaks that cycle in 2 days with an advanced 5-in-1 gut barrier repair formula. [2]

  • Poop every morning without straining*
  • Feel confident in fitted clothes*
  • Enjoy meals without fear*
  • Stop planning your day around bathrooms*
  • Go to bed feeling light*
  • 100% Money-Back Guarantee
  • Free Shipping
  • Cancel Anytime
  • Delayed-Release Capsules
  • Third-Party Tested
  • FDA & GMP
  • Vegan
  • Non-GMO
  • Gluten-Free
  • Manufactured in USA

BENEFITS OF OUR INGREDIENTS ARE RESEARCHED BY

Join 47,000+ Bioma's Customers Who Went From Backed Up To Regular, Smooth Poops in 2 Days

BASED ON 3,547 VERIFIED REVIEWS

Michael T.
I've tried EVERYTHING... fiber, probiotics, laxatives and nothing worked long term. Bioma gave me relief in 3 days and I've been regular ever since... I actually look forward to my mornings now!
Sarah M.
No more painful straining. No more planning my route and day around where the next clean bathroom is... The first thing that actually worked for me. Thank you!!!
Jessica K.
I was skeptical about the 48-72 hours claim but all I can say is WOW.. I mean by the end of day 2 I felt lighter, less bloated and actually pooped without forcing it. My pants fit better too...

95% of Americans are Butyrate-Deficient

Butyrate is your colon’s #1 fuel source. A short-chain fatty acid produced when healthy gut bacteria digest fiber.

Think  of it as “superfuel” for your intestinal cells.

Here's what it does:
✓ Powers your colon cells - Provides 60-70% of their energy needs

Seals your gut lining - Repairs damaged gut barrier and maintains tight junctions

Drives muscle contractions - Moves waste through your digestive tract

Controls inflammation - Keeps your immune system balanced

Without enough butyrate, your gut barrier weakens, inflammation increases, and digestion slows to a crawl.

That's why you are constipated and can't poop regularly.

Your body doesn’t make butyrate, your gut bacteria do. But modern life has wiped out the bacteria responsible for producing it.

The 3 Main culprits:
1. Low-fibre diets
Butyrate is produced when gut bacteria ferment fiber. Most Americans eat less than half the recommended fiber intake, starving the bacteria that make butyrate.
2. Antibiotics
Even a single course of antibiotics can wipe out butyrate-producing bacteria for months. Many never fully recover.
3. Chronic stress
Stress hormones kill beneficial bacteria and promote harmful bacteria that don’t produce butyrate.

   The result is that 95% of Americans can't produce enough butyrate to maintain a healthy gut barrier.

“The Constipation Trap” is a vicious cycle where constipation literally causes more constipation.

Here's how it works:

And it gets worse with age. Butyrate production by your gut bacteria declines up to 50% as you get older.

You’re trapped because:

  • Your damaged gut can’t produce butyrate
  • Without butyrate, your gut can’t heal
  • Your constipation prevents the bacterial activity needed to make butyrate
  • The cycle repeats itself

If you’ve tried everything with no lasting results, here’s why traditional solutions don’t work:

  1. Fiber Supplements
    Fiber only helps if you have the right bacteria to ferment it into butyrate. Without those bacteria (which 95% of Americans lack), fiber just sits in your gut, ferments improperly, and causes MORE bloating and gas.
  2. Generic probiotics
    95% of probiotic bacteria die in your stomach acid before reaching your colon where they’re needed. The few that survive can’t colonize your inflamed, damaged gut environment, in other words they starve without butyrate.Plus, most probiotics don’t even contain butyrate-producing strains.
  3. Laxatives
    Laxatives force unnatural muscle contractions without healing anything. Over time, they:
    • Create dependency (your gut “forgets” how to move on its own)
    • Damage your protective mucus lining
    • Weaken natural peristalsis
    • Leave your worse than when you started

None of these address the root cause: Your damaged gut barrier and butyrate deficiency.

Butyrate is your colon's #1 fuel source. A short-chain fatty acid produced when healthy gut bacteria digest fiber.

Think of it as 'superfuel' for your intestinal cells.

Bioma’s Digestive & Gut Repair Probiotics use a unique 5-step formula to address the root cause of your constipation: butyrate deficiency and gut barrier damage.


SEAL - CoreBiome® Tributyrin (150mg)
Delivers butyrate directly to your colon to repair the gut barrier in 2 days.

FEED - FOS + Acacia Fiber (250mg)
Feeds beneficial bacteria like Bifidobacteria. Increases good bacteria and improves bowel movement frequency.

RESTORE - Howaru Restore® (10 Billion CFU)
4 clinically-studied probiotic strains in delayed-release capsules. 52% faster recovery from digestive distress.

DIGEST - Bromelain + Papain (100mg each)
Digestive enzymes that break down food, prevent fermentation, and reduce bloating.

STRENGTHEN - Hōlistiq™ Mushroom Beta-Glucans (100mg)
6 organic mushrooms that reduce inflammation and strengthen your gut-immune connection.

Bioma doesn’t just treat symptoms, it repairs the foundation. You break free from the “Constipation Trap” because your gut can finally produce butyrate again.

What Happens When You Fix Your Gut The Scientifically Proven Way

Highest Standards of Quality, Powerhouse Ingredients, All Backed By Science

Initial Relief

Days 1-3 (48-72 Hours)

What's happening: Gut barrier repair begins, inflammation decreases, motility improves

What you'll notice:

  • Less bloating after meals
  • Reduced cramping
  • Easier bowel movements starting
Regularity Restored

Weeks 1-2

What's happening: Good bacteria multiply, probiotics colonize, enzymes optimize digestion

What you'll notice:

  • Consistent daily bowel movements
  • No more straining or forcing
  • Feel lighter and more energized
Full System Reset

Months 1-2

What's happening: Gut barrier fully repaired, microbiome rebalanced, natural butyrate production restored

What you'll notice:

  • Complete regularity (no surprises)
  • Clothes fit noticeably better
  • Eat wider variety of foods
  • Better mood and sleep quality
  • Zero bathroom anxiety
Deep Optimization

Months 3-4

What's happening: Microbiome diversity peaks, immune strengthening, peak digestive efficiency, inflammation markers drop significantly

What you'll notice:

  • Zero bloating, even after big meals
  • Better stress resilience
  • Clearer, more radiant skin
  • Fewer food sensitivities
  • Feel 'bulletproof' digestively
Peak Performance & Protection

Months 5-6+

What's happening: Self-sustaining microbiome, lasting gut barrier strength, metabolic health improvements, anti-aging benefits from butyrate, peak immune function

What you'll notice:

  • Effortless digestion is your new normal
  • Sustained weight management
  • Enhanced mental clarity and focus
  • Overall vitality boost
  • Fewer sick days
  • Forgot what constipation feels like
  • Friends notice you look healthier

Why Choose a 6-Month Supply?

Months 1-2

Fix the problem

Months 3-4

Optimize system

Months 5-6

Lock in transformation

"This is more than just a supplement, it's a lifestyle change."

Jennifer K., 6+ Months

What’s Inside Your Bioma Bottle

Highest Standards of Quality, Powerhouse Ingredients, All Backed By Science

Ingredients
  • Prebiotics
    Fructo-Oligosaccharides (FOS) nourish good bacteria like Bifidobacteria and Lactobacilli. These strains of good bacteria restore balance in your microbiome to ease bloating, improve regularity, and support lasting gut health.

  • Probiotics
    10 Billion CFU of clinically proven Howaru® Restore strains help rebuild a healthy gut flora, improve digestion, and maintain regularity – even when diet, travel, or stress throw you off balance.

  • Postbiotics
    Tributyrin from CoreBiome® helps strengthen the gut lining for better nutrient absorption, reduced inflammation, and protection against toxins. Laboratory research shows it begins supporting barrier function within just 48 hours [1], and benefits may appear within as little as 7 days.*

  • Digestive Enzymes
    A natural blend of Bromelain and Papain helps break down heavy meals more efficiently. This relieves bloating, gas, and lets you enjoy food without discomfort.

  • Mushroom Beta - Glucans
    Our mushroom complex feeds the bacteria that build your gut barrier, helps convert food into clean energy, and triggers immune cells to wake up and do their job. This means less irritation, better resilience, and more balanced immune responses.

How to take

Take 2 capsules daily with a glass of water, preferably with a meal.

For best results:

  • Take consistently at the same time each day
  • Continue for at least 2-3 months (best 6+) to allow your gut to fully reset
  • Safe for long-term daily use


Start in the morning to establish a routine, or take with your largest meal for optimal digestion support.

Why Delayed-Release Capsules Matter

Most probiotics fail because 95% of bacteria die in your stomach acid before reaching your colon[13], where you actually need them.

Bioma delayed-release capsules solve this:
✓ Protect ingredients from stomach acid
✓ Deliver probiotics alive to your colon where they can colonize
✓ Release butyrate exactly where your gut barrier needs it
✓ Maximize effectiveness of every ingredient

That’s why Bioma works when generic probiotics fail, your gut actually receives what’s on the label.

What Makes Our 5-in-1 Formula Different

Most probiotics only add bacteria, but if your gut barrier is damaged, it’s like planting flowers in front of a burning house.

Bioma’s 5-in-1 system breaks the Constipation Trap by repairing the foundation first:
🛡️ SEAL - CoreBiome® butyrate repairs your damaged gut barrier in 2 days
🌱 FEED - Prebiotic fiber feeds beneficial bacteria
🦠 RESTORE - 4 clinically-studied probiotic strains replenish good bacteria
⚙️ DIGEST - Enzymes break down food to prevent fermentation
🛡️ STRENGTHEN - Mushroom beta-glucans reduce inflammation

Unlike generic probiotics that just add bacteria, Bioma addresses the root cause, your damaged gut barrier and butyrate deficiency, so your gut can heal and produce butyrate naturally again.

Bioma vs. Everything Else You've Tried

What You Need
Seals Gut Barrier
Yes
No
No
No
Clinical-Grade Postbiotic
Yes
No
No
No
Feeds Good Bacteria
Yes
Partial
No
No
Survives Stomach Acid
Yes
Yes
No
Yes
10 Billion CFU Probiotics
Yes
No
Varies
No
Digestive Enzymes
Yes
No
No
No
Immune Support
Yes
No
Limited
No
Works in 48 hours
Yes
No
No
Yes
Addresses Root Cause
Yes
No
No
No
Safe Long-Term
Yes
Yes
Yes
No
No Dependency
Yes
Yes
Yes
No

Choose Your BIOMA Package And Put An End To The Constipation Trap

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Third-Party Tested
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Gluten-Free | Vegan
Gluten-Free | Vegan
Organic Mushrooms
Organic Mushrooms
Dark Glass Bottles for Product Quality
Dark Glass Bottles for Product Quality
Delayed-Release Capsules
Delayed-Release Capsules
100% Natural & Non-GMO
100% Natural & Non-GMO
Manufactured in USA
Manufactured in USA
Guarantee

100% Money-Back Guarantee

We're so confident BIOMA Digestive and Gut Repair Probiotics will transform your digestive health and end constipation trap, that we offer a complete money-back guarantee.

If you don't see meaningful improvement in your constipation within 14 days, simply contact us for a full refund. No questions asked.

100% Money-Back Guarantee
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Cancel Anytime

Our Customers Talk About Bioma

Gut Repair Formula, Backed by Science

FDA & GMP Certified
FDA & GMP Certified
Third-Party Tested
Third-Party Tested
Secure Checkout
Secure Checkout
Gluten-Free | Vegan
Gluten-Free | Vegan
Organic Mushrooms
Organic Mushrooms
Dark Glass Bottles for Product Quality
Dark Glass Bottles for Product Quality
Delayed-Release Capsules
Delayed-Release Capsules
100% Natural & Non-GMO
100% Natural & Non-GMO
Manufactured in USA
Manufactured in USA

Frequently Asked Questions

Get answers to common questions about BIOMA

Most customers notice less bloating and easier bowel movements within the first 48-72 hours. Full gut repair and consistent regularity typically occurs within 2-4 weeks as your gut barrier heals and microbiome rebalances.

Yes. Bioma is formulated with natural, clinically-tested ingredients and is designed for daily, long-term use. It's manufactured in FDA-registered, GMP-certified facilities and is third-party tested for purity and potency. Unlike laxatives, Bioma doesn't create dependency.

Traditional probiotics only add bacteria, most of which die in stomach acid. Bioma uses delayed-release capsules AND repairs your gut barrier FIRST with CoreBiome® postbiotic. This creates a healthy environment where probiotics can actually survive and thrive.

Many of our customers have IBS-C (IBS with constipation), chronic constipation, or other digestive issues. Bioma addresses the root cause, gut barrier dysfunction, which underlies many digestive problems. However, we recommend consulting your doctor if you have severe conditions

We offer a 100% money-back guarantee. If you don't see meaningful improvement within 14 days, simply contact our customer service team for a full refund. No questions asked. We take all the risk so you don't have to.

100% Money-Back Guarantee
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References

[1] - Quagliani D, Felt-Gunderson P. Closing America's Fiber Intake Gap: Communication Strategies From a Food and Fiber Summit. Am J Lifestyle Med. 2016 Jul 7;11(1):80-85. https://pmc.ncbi.nlm.nih.gov/articles/PMC6124841/
[2] - Vance A, Raut S, Grier-Welch A, Alamdari N, Sharafi M. A Novel Combination of Pre-, Pro-, and Postbiotics Demonstrates Protective Effects on Intestinal Permeability in an In Vitro Gut Barrier Model. eBioMedicine. 2024;106:105247. https://www.sciencedirect.com/science/article/pii/S2475299123208707 

[3] - Kirschner SK, Engelen MPKJ, Haas P, et al. Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial. Am J Clin Nutr. 2025 Jun;121(6):1224-1235. https://pubmed.ncbi.nlm.nih.gov/40274191/ 
[4] - Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011 Mar 28;17(12):1519-28.  https://pubmed.ncbi.nlm.nih.gov/21472114/
[5] - Peng L, Li ZR, Green RS, Holzman IR, Lin J. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr. 2009 Sep;139(9):1619-25. https://pubmed.ncbi.nlm.nih.gov/19625695/ 
[6] - Willing BP, Russell SL, Finlay BB. Shifting the balance: antibiotic effects on host-microbiota mutualism. Nat Rev Microbiol. 2011 Apr;9(4):233-43. https://pubmed.ncbi.nlm.nih.gov/21358670/ 
[7] - Karl JP, Hatch AM, Arcidiacono SM, Pearce SC, Pantoja-Feliciano IG, Doherty LA, Soares JW. Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota. Front Microbiol. 2018 Sep 11;9:2013. https://pubmed.ncbi.nlm.nih.gov/30258412/
[8] - Shepherd SJ, Parker FC, Muir JG, Gibson PR. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol. 2008 Jul;6(7):765-71. https://pubmed.ncbi.nlm.nih.gov/18456565/
[9] - Dodoo CC, Wang J, Basit AW, Stapleton P, Gaisford S. Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation. Int J Pharm. 2017 Jul 15;530(1-2):224-229. https://discovery.ucl.ac.uk/id/eprint/1568933/1/Gaisford_IJP%20probiotics%20R1.pdf 
[10] - Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum. 2001 Aug;44(8):1201-9. https://pubmed.ncbi.nlm.nih.gov/11535863/