DIGESTIVE & GUT REPAIR PROBIOTICS

Why You’re Bloated And Can’t Lose Weight No Matter How “Clean” You Eat

It’s not willpower. It’s not your diet. 95% of Americans are fiber-deficient[1], starving their gut of the ONE compound that seals your gut barrier, stops inflammation, and unlocks natural weight loss.
  • Wake up with a flat, comfortable stomach*
  • Finally fit into your favorite jeans again*
  • Eat without fear of “food baby” bloat*
  • Support healthy weight management naturally*
  • Feel lighter and more energized all day*
END BLOATING & WEIGHT GAIN
  • 100% Money-Back Guarantee
  • Free Shipping
  • Cancel Anytime
  • Delayed-Release Capsules
  • Third-Party Tested
  • FDA & GMP
  • Vegan
  • Non-GMO
  • Gluten-Free
  • Manufactured in USA

BENEFITS OF OUR INGREDIENTS ARE RESEARCHED BY

Choose Your BIOMA Package and Break Free From The Bloat-Weight Cycle

Cancel Anytime
Free Shipping On All Orders
100% Money-Back Guarantee
Try It Out SAVE 40%

1-Month Supply

Perfect for trying out

$53.99per bottle
$89.99
  • 30 servings ($1.79/day)
  • See initial results in 2 weeks
  • 1 bottle delivered

Cancel anytime. Free shipping

Try It Out Save 20%

1-Month Supply

Perfect for trying out

$71.99per bottle
$89.99
  • 30 servings ($2.39/day)
  • See initial results in 2 weeks
  • 1 bottle delivered

Cancel anytime

Most Popular SAVE 45%

3-Month Supply

Build healthy habits

$49.49per bottle
$89.99
  • 90 servings ($1.64/day)
  • Establish daily regularity
  • 3 bottles delivered

Cancel anytime. Free shipping

Most Popular Save 30%

3-Month Supply

Build healthy habits

$62.99per bottle
$89.99
  • 90 servings ($2.09/day)
  • Establish daily regularity
  • 3 bottles delivered

Cancel anytime

Best Value SAVE 50%

6-Month Supply

Full gut repair cycle

$44.99per bottle
$89.99
  • 180 servings ($1.49/day)
  • Complete digestive freedom
  • 6 bottles delivered

Cancel anytime. Free shipping

Best Value Save 35%

6-Month Supply

Full gut repair cycle

$58.49per bottle
$89.99
  • 180 servings ($1.94/day)
  • Complete digestive freedom
  • 6 bottles delivered

Cancel anytime

Plans renews automatically till cancelled

Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
  • FDA & GMP Certified Facilities
  • Third-Party Tested
  • Secure Checkout
  • Gluten-Free | Vegan
  • Organic Mushrooms
  • Dark Glass Bottles for Product Quality
  • Delayed-Release Capsules
  • 100% Natural & Non-GMO
  • Manufactured in USA

Join 47,000+ Bioma’s Customers Who Went From 
Being Bloated To Feeling Normal Again

BASED ON 3.347 VERIFIED REVIEWS

Amanda R.
I was bloated 24/7 and couldn't lose weight no matter what I tried. Within 3 days of taking Bioma, my stomach was FLAT for the first time in years. And I've lost 12 lbs in 6 weeks without changing my diet. This is life-changing!
Amanda R.
Verified Customer
David K.
My wife said I look 10 pounds lighter just from the bloating going down. The constant puffiness after every meal is just… gone. I wish I'd found this years ago.
David K.
Verified Customer
Lauren M.
I thought I was gaining weight, but it turned out to be chronic bloating from a damaged gut. Bioma fixed it in days. My pants fit better, my face looks thinner, and I actually have energy now.
Lauren M.
Verified Customer
Read 3,000+ More Reviews

Why You Feel Bloated After Every Meal And Why That Same Bloating Is Making It Impossible To Lose Weight

If you’re constantly bloated, and you’re struggling to lose weight despite eating “clean,” the problem isn’t your willpower or your diet.

It’s your damaged gut barrier.

Your gut barrier is a protective lining with a surface area of over 300 square feet. But it’s only one cell thick. Despite being ultra-thin, when it’s healthy, it’s incredibly strong[2][3][4][5].
When it's healthy:
  • Nutrients get absorbed efficiently
  • Harmful toxins stay blocked out
  • Inflammation stays low
  • Your metabolism functions normally
  • You feel light and comfortable after meals
  • Weight management is easier

But here’s where things go wrong…

To stay healthy and strong, your gut needs a compound called butyrate to function[6].

You can think of butyrate as “metabolic fuel” that seals your damaged gut lining, reduces inflammation, and signals your body to burn fat instead of storing it.[8][6]

Your gut barrier is only ONE CELL THICK

It needs butyrate as fuel to maintain tight junctions and protect you from inflammation and toxins into your bloodstream[7].

Without butyrate, tight junctions break down

Toxins and bacterial fragments (LPS) lead into your bloodstream, triggering a metabolic firestorm that causes bloating and signals your body to store fat, especially around your belly[9][10].

This creates the Bloat-Weight Cycle

Inflammation from the “leaky gut” causes bloating, disrupts hormones (insulin, cortisol, leptin), slows metabolism, and promotes fat storage. The weight gain changes your gut bacteria, producing even less butyrate. The cycle perpetuates itself[11][12].
So here’s the real problem.

95% of Americans are butyrate-deficient[1]

And it gets worse with age. After 40, research shows butyrate production declines significantly with age, by up to 50% in older adults, which is why bloating and stubborn weight gain get progressively worse[13][14][15].

This creates a vicious cycle, what we call the “BLOAT-WEIGHT CYCLE”:
TRY BIOMA RISK-FREE

… and the cycle repeats.

You’re trapped in the Bloat-Weight Cycle where bloating and weight gain feed each other.

So even if you try to “fix” this by eating salads, doing intermittent fasting, cutting carbs, or taking generic probiotics, the truth is that these “solutions” will only mask symptoms at best,and that’s why the bloating and stubborn weight always come back.

Healthy foods like vegetables contain fiber that ferments in your gut. When your barrier is damaged, this fermentation creates excess gas and inflammation, making bloating worse. You need to seal the barrier first. Then your gut can properly digest fiber[16]17].
When toxins (LPS) leak through your damaged gut barrier, they trigger systemic inflammation. This inflammation disrupts insulin signaling, causing your body to store calories as fat instead of burning them for energy, even in a calorie deficit. It also elevates cortisol, which specifically promotes belly storage[9][10][11][18].
When toxins (LPS) leak through your damaged gut barrier, they trigger systemic inflammation. This inflammation disrupts insulin signaling, causing your body to store calories as fat instead of burning them for energy, even in a calorie deficit. It also elevates cortisol, which specifically promotes belly storage[9][10][11][18].
Butyrate. It’s your gut’s primary fuel source. Multiple studies show production declines significantly with age, which is why bloating and weight gain get worse over time[6][13][14][15].
Chronic stress elevates cortisol, a hormone that dictates where fat is stored in your body. High cortisol signals your body to store fat centrally, around your organs (visceral fat). It also disrupts gut-brian communication, slowing digestion and causing bloating[20][21][22].

Why Diets, “Debloat” Teas, and Generic Probiotics Failed You

If you’ve tried everything with no lasting results… It’s not your fault.

Here's why...
Without healing your gut barrier first, eliminating foods only temporarily reduces symptoms while it doesn’t address the underlying drivers of symptoms for many people[16][17].

WHAT THEY SAY:

“Just avoid trigger foods and you’ll feel better”.

THE REALITY:

“Youre treating symptoms, not the cause. Your gut barrier is stil damaged and leaking toxins. The bloating and weight gain will return the moment you eat normally.”
95% die in stomach acid before reaching your colon. The few survivors can’t thrive in a damaged, inflamed gut environment, and they don’t address the root cause: your broken gut barrier[19].

WHAT THEY SAY:

“Add good bacteria and you’ll lose weight and debloat.” 

THE REALITY:

“95% die before reaching your gut. The survivors starve because your inflamed gut can’t produce the butyrate they need. You’re pouring water into a bucket with holes in it.”
They force temporary water loss or bowel movements but but can disrupt your gut microbiome and deplete beneficial bacteria over time, making it harder for your gut to function naturally.[23]

WHAT THEY SAY:

“Flush out toxins and bloating disappears.”

THE REALITY:

“You're dehydrating yourself and reducing beneficial gut bacteria. The bloating returns within hours, and you've disrupted your gut microbiome.”
And none of these address the root cause:

REPAIRING YOUR GUT BARRIER.

Not addressing your damaged gut barrier leads to “metabolic endotoxemia”.
 This is a condition, (triggered by “leaky gut”),  where bacterial toxins (LPS) continuously leak into your bloodstream. They trigger the chronic inflammation that causes bloating, disrupts your metabolism, and promotes fat storage, creating what we call the “BLOAT-WEIGHT CYCLE” amongst other health issues[9][10].

Try Bioma Risk-Free

Healthy Gut

  • Produces butyrate naturally
  • Flat stomach after meals
  • Metabolism burns calories efficiently
  • Healthy weight maintenance
  • Feel light and energized

Damaged Gut

  • Butyrate deficient (95% of Americans)[1]
  • Bloated after every meal
  • Inflammation disrupts insulin → fat storage[9][10][11]
  • Stubborn weight gain (especially belly fat)[9][10][11]
  • Feel heavy, sluggish, and puffy

So if traditional solutions don’t work… what does?

You need to repair the foundation of your gut first.

Introducing The Revolutionary 5-Step Gut Repair System That Breaks The Constipation Trap

Unlike traditional probiotics, BIOMA’s Digestive & Gut Repair takes care of your gut barrier FIRST, then rebuilds your microbiome

Traditional Approach

  • Add probiotics to damaged gut
  • Most die in stomach acid[19]
  • Temporary relief (maybe)
  • Single mechanism

Bioma's Approach

  • Seal gut barrier FIRST
  • Delayed-release capsules
  • Lasting transformation
  • 5-in-1 system
See How It Works

Most supplements try to add probiotics or fiber to a broken gut system. But it’s like trying to fill up a bucket that has holes in it.

BIOMA Digestive & Gut Repair Probiotics work differently.

It contains CoreBiome® Tributyrin, the world's first and only clinically-proven postbiotic that delivers butyrate directly to your colon and begin to seal your gut barrier in as little as 2 days.[24]
Once your gut is sealed, inflammation drops, bloating disappears, and your metabolism can function normally again, making healthy weight management natural.

That’s why Bioma includes prebiotics to feed good bacteria, probiotics that actually survive your stomach acid (due to delayed-release capsules), digestive enzymes to prevent bloating, and immune support, all working in sequence.
Step 1

Seal Your Gut Barrier

CoreBiome® Tributyrin (150mg)
Postbiotic
What Is It:
The world's only fermented tributyrin that releases butyrate directly in your colon.​
Why It Matters for Bloating & Weight:
Strengthens tight junctions, reduces inflammation, nourishes intestinal cells. Stops toxins from leaking into your bloodstream. Improved gut barrier in just 2 days.​[24]
The Result:

Your gut can function normally again. Less bloating, better metabolism.

Step 2

Feed Your Good Bacteria

FOS + Acacia Fiber (250mg)
Prebiotics​
What Is It:
Food for beneficial bacteria like Bifidobacteria and Lactobacilli.
Why It Matters for Bloating & Weight:
Increases beneficial bacteria that produce butyrate naturally, reduces bloating, supports healthy metabolism.
Research-backed:
Increases Bifidobacteria and improves bowel frequency in clinical studies.[25]
The Result:

Your gut maintains a balanced microbiome.

Step 3

Replenish Beneficial Strains

Howaru Restore® (10 Billion CFU)
Probiotics
What Is It:
4 clinically-studied strains in delayed-release capsules.

Strains included:
  • Lactobacillus acidophilus NCFM®
  • Lacticaseibacillus paracasei Lpc-37®
  • Bifidobacterium lactis Bl-07®
  • Bifidobacterium lactis Bl-04®
Why It Matters for Bloating & Weight:
Restores microbial balance, reduces bloating, supports healthy weight management.
Clinical proof:
52% faster recovery​ from digestive distress.[26][27]
The Result:

Your gut flora works in harmony to support comfortable digestion and healthy weight.

Step 4

Break Down Food Efficiently

Bromelain + Papain (100mg each)
Digestive Enzymes
What Is It:
Proteolytic enzymes from pineapple and papaya
Why It Matters for Bloating & Weight:
Prevents food fermentation, reduces bloating, improves nutrient absorption, minimizes backup.[28]
Research-backed:
Digestive enzyme combinations clinically shown to reduce bloating and improve digestive comfort.[29]
The Result:

Food moves smoothly through your system without bloating or heaviness.

Step 5

Strengthen Immune Defense

Hōlistiq™ Mushroom Beta-Glucans (100mg)
Immune Support​
What Is It:
6 organic medicinal mushrooms (Cordyceps, Reishi, King Trumpet, Shiitake, Lion’s Mane, Turkey Tail)
Why It Matters for Bloating & Weight:
Feeds beneficial bacteria, reduces inflammation, strengthens gut-immune axis.[30]
Research-backed:
Beta-glucans from medicinal mushrooms increase butyrate-producing bacteria and help modulate inflammatory responses that contribute to bloating and weight gain.[31]
The Result:

Your gut becomes more resilient and inflammation stays low.

Get BIOMA Now
  • 100% Money-Back Guarantee
  • Free Shipping
  • Cancel Anytime

What Happens When You Fix Your Gut The Scientifically Proven Way

Here’s exactly what to expect when you start BIOMA

Initial Relief

Days 1-3 (48-72 Hours)

What's happening: Gut barrier repair begins, inflammation decreases, toxin leakage reduces.

What you'll notice:

  • Less bloating after meals
  • Stomach feels flatter in the morning*
  • Less puffiness in face and midsection*
Visible Changes Begin

Weeks 1-2

What's happening: Good bacteria multiply, probiotics colonize, enzymes optimize digestion.

What you'll notice:

  • Consistent flat stomach throughout the day*
  • Clothes fit more comfortably (especially around waist)*
  • More energy and mental clarity*
  • Friends start noticing you look “lighter”*
Full System Reset

Months 1-2

What's happening: Gut barrier fully repaired, microbiome rebalanced, natural butyrate production restored.

What you'll notice:

  • Weight loss become easier*
  • Zero bloating, even after big meals*
  • Face looks noticeably slimmer*
  • Sustained energy all day*
  • Clothes are loose/need new size*
Deep Optimization

Months 3-4

What's happening: Microbiome diversity peaks, metabolism functions normally, fat burning increases.

What you'll notice:

  • Total body transformation visible*
  • Maintained flat stomach becomes your "new normal"*
  • Better stress resilience*
  • Skin looks clearer and more radiant*
  • Feel 'bulletproof' digestively*
Peak Performance & Long-Term Health

Months 5-6+

What's happening: Self-sustaining microbiome, lasting gut barrier strength, metabolic health optimized, cellular health from butyrate, peak immune function.

What you'll notice:

  • Effortless weight maintenance at your ideal weight*
  • Can enjoy foods without bloating or weight gain*
  • Enhanced mental clarity and mood*
  • Overall vitality boost*
  • Stronger immune support*
  • Look and feel years younger*

Why Choose a 6-Month Supply?

Months 1-2

Fix the problem

Months 3-4

Optimize metabolism

Months 5-6

Lock in transformation

"This is more than just a supplement, it’s a body reset. I lost 18 lbs, my bloating is gone, and I feel like myself again for the first time in a decade"

Joanna L., 6+ Months

Choose Your BIOMA Package and Break Free From The Bloat-Weight Cycle

Cancel Anytime
Free Shipping On All Orders
100% Money-Back Guarantee
Try It Out SAVE 40%

1-Month Supply

Perfect for trying out

$53.99per bottle
$89.99
  • 30 servings ($1.79/day)
  • See initial results in 2 weeks
  • 1 bottle delivered

Cancel anytime. Free shipping

Try It Out Save 20%

1-Month Supply

Perfect for trying out

$71.99per bottle
$89.99
  • 30 servings ($2.39/day)
  • See initial results in 2 weeks
  • 1 bottle delivered

Cancel anytime

Most Popular SAVE 45%

3-Month Supply

Build healthy habits

$49.49per bottle
$89.99
  • 90 servings ($1.64/day)
  • Establish daily regularity
  • 3 bottles delivered

Cancel anytime. Free shipping

Most Popular Save 30%

3-Month Supply

Build healthy habits

$62.99per bottle
$89.99
  • 90 servings ($2.09/day)
  • Establish daily regularity
  • 3 bottles delivered

Cancel anytime

Best Value SAVE 50%

6-Month Supply

Full gut repair cycle

$44.99per bottle
$89.99
  • 180 servings ($1.49/day)
  • Complete digestive freedom
  • 6 bottles delivered

Cancel anytime. Free shipping

Best Value Save 35%

6-Month Supply

Full gut repair cycle

$58.49per bottle
$89.99
  • 180 servings ($1.94/day)
  • Complete digestive freedom
  • 6 bottles delivered

Cancel anytime

Plans renews automatically till cancelled

Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
Payment method
  • FDA & GMP Certified Facilities
  • Third-Party Tested
  • Secure Checkout
  • Gluten-Free | Vegan
  • Organic Mushrooms
  • Dark Glass Bottles for Product Quality
  • Delayed-Release Capsules
  • 100% Natural & Non-GMO
  • Manufactured in USA
Guarantee

100% Money-Back Guarantee

We’re so confident BIOMA Digestive and Gut Repair Probiotics will relieve your bloating and support healthy weight management, that we offer a complete money-back guarantee.

If you don’t see meaningful improvement in your bloating and weight within 14 days, simply contact us for a full refund. No questions asked.

We take all the risk so you don’t have to. Your only risk is staying bloated and frustrated.
Try BIOMA Risk-Free Today
100% Money-Back Guarantee
Free Shipping
Cancel Anytime

Our Customers Talk About Bioma

What’s Inside Bioma’s Digestive & Gut Repair Probiotics

Highest Standards of Quality, Powerhouse Ingredients, 
All Backed By Science

Prebiotics

Fructo-Oligosaccharides (FOS) + Acacia Fiber nourish good bacteria like Bifidobacteria and Lactobacilli. These strains restore balance in your microbiome to ease bloating, support healthy weight management, and promote lasting gut health.

Probiotics

10 Billion CFU of clinically-proven Howaru Restore® strains help rebuild a healthy gut flora. Improves digestion, supports healthy weight management, and maintains regularity even when diet, travel, or stress throw you off balance.

Postbiotics

Tributyrin from CoreBiome® is the breakthrough form of SCFA butyrate that aids GI function, strengthens intestinal lining for reduced bloating, reduced inflammation, protection against toxins, and support for healthy metabolism.

Digestive Enzymes

A powerful blend of Bromelain and Papain are proteolytic enzymes that help break down proteins into smaller, easier-to-digest peptides and amino acids. This reduces bloating, gas, and post-meal heaviness while helping you absorb more nutrients and feel lighter fast.

Mushroom Beta - Glucans

Our mushroom complex feeds the bacteria that build your gut barrier, helps convert food into clean energy, and triggers immune cells to reduce inflammation, and supports a diverse microbiome. This means less bloating, better metabolism, and more balanced immune responses.

Take 2 capsules daily with a glass of water, preferably with a meal.

For best results:
  • Take consistently at the same time each day
  • Continue for at least 2-3 months (best 6+) to allow your gut to fully reset
  • Safe for long-term daily use

Start in the morning to establish a routine, or take with your largest meal for optimal digestion support.

Most probiotics fail because 95% of bacteria die in your stomach acid before reaching your colon, where you actually need them.[19]

Bioma delayed-release capsules solve this:
  • Protect ingredients from stomach acid
  • Deliver probiotics alive to your colon where they can colonize
  • Release butyrate exactly where your gut barrier needs it
  • Maximize effectiveness of every ingredient

That’s why Bioma works when generic probiotics fail, your gut actually receives what’s on the label.

Most probiotics only add bacteria, but if your gut barrier is damaged, it’s like planting flowers in front of a burning house.

Bioma’s 5-in-1 system breaks the Bloat-Weight Cycle by repairing the foundation first:
  • SEAL - CoreBiome® butyrate repairs your damaged gut barrier in 2 days[24][32]
  • FEED - Prebiotic fiber feeds beneficial bacteria that support metabolism
  • RESTORE - 4 clinically-studied probiotic strains replenish good bacteria
  • DIGEST - Enzymes break down food to prevent bloating and gas
  • STRENGTHEN - Mushroom beta-glucans reduce inflammation

That’s why Bioma works when generic probiotics fail, your gut actually receives what’s on the label.

Supplement Facts

Manufacturing Excellence

  • FDA & GMP Certified Facilities
  • Delayed-Release Capsules
  • Cold-Chain Processing
  • Strict Quality Controls

Quality Testing

  • Third-Party Lab Tested
  • Certificate of Analysis
  • Purity & Potency Verified
  • Stability Guaranteed

Clean Formula

  • 100% Vegan & Non-GMO
  • Gluten & Allergen Free
  • No Artificial Additives
  • No Fillers or Preservatives
Order BIOMA Now
  • 100% Money-Back Guarantee
  • Free Shipping
  • Cancel Anytime

Imagine Waking Up Tomorrow With a Flat Stomach, and Your Ideal Weight Within Reach

This could be your new reality in just 48 hours*

No more..

  • Bloating after every meal
  • Feeling 5-10 lbs heavier from bloating
  • Avoiding fitted clothes or tucking in shirts
  • Stubborn weight that won't budge
  • Trying diet after diet with no results
  • Feeling heavy and sluggish after meals
  • Constant digestive discomfort
  • Puffy face and midsection
  • Feeling frustrated and defeated
.
With Bioma Digestive & Gut Repair Probiotics

Instead, you'll experience...

  • A flat, comfortable stomach all day long
  • Looking noticeably slimmer and more defined
  • Confidence to wear anything you want
  • Natural, sustainable weight loss*
  • Easy weight management without restriction
  • Light, energized, and ready to move
  • Comfortable, smooth digestion you can rely on
  • A sculpted, lean appearance
  • True freedom and confidence in your body

The choice is yours. Stay trapped in the Bloat-Weight Cycle, or break free in 48 hours*

START YOUR GUT REPAIR JOURNEY TODAY
  • Zero Risk - 100% Satisfaction Guarantee
  • Free Shipping
  • Cancel Anytime

Join thousands who’ve already broken free from bloating and achieved their ideal weight.

Frequently Asked Questions

Get answers to common questions about BIOMA

Most customers notice less bloating and a flatter stomach within the first 48-72 hours. Visible changes in weight and body composition typically occur within 2-4 weeks as your gut barrier heals, inflammation decreases, and your metabolism normalizes. For complete body transformation and sustained weight management, we recommend 3-6 months*.
Yes. Bioma is formulated with natural, clinically-tested ingredients and is designed for daily, long-term use. It's manufactured in FDA-registered, GMP-certified facilities and is third-party tested for purity and potency. Unlike harsh "detoxes" or laxatives, Bioma doesn't create dependency, it repairs your gut naturally.
Traditional probiotics only add bacteria, most of which die in stomach acid. Bioma uses delayed-release capsules AND repairs your gut barrier FIRST with CoreBiome® postbiotic. This supports healthy inflammation levels and addresses the factors that contribute to both bloating AND weight management challenges, so your body can naturally return to its healthy weight.
Many of our customers managing digestive challenges report positive experiences with Bioma. The product supports gut barrier integrity and healthy inflammation balance, which are foundational to digestive wellness. However, Bioma is a dietary supplement, not a medical treatment. If you have diagnosed conditions like IBS, PCOS, or thyroid disorders, or are taking prescription medications, please consult your healthcare provider before use to ensure this product is appropriate for your individual situation.
We offer a 100% money-back guarantee. If you don't see meaningful improvement in bloating and digestive comfort within 14 days, simply contact our customer service team for a full refund. No questions asked. We take all the risk so you don't have to.
Order BIOMA Now
100% Money-Back Guarantee
Free Shipping
Cancel Anytime

References

[ 1 ] Quagliani D, Felt-Gunderson P. Closing America's Fiber Intake Gap. Am J Lifestyle Med. 2016. https://pmc.ncbi.nlm.nih.gov/articles/PMC6124841/

[ 2 ] Helander HF, Fändriks L. Surface area of the digestive tract - revisited. Scand J Gastroenterol. 2014. https://pubmed.ncbi.nlm.nih.gov/24694282/

[ 3 ] Ramanan D, Cadwell K. Intrinsic Defense Mechanisms of the Intestinal Epithelium. Cell Host Microbe. 2016. https://pmc.ncbi.nlm.nih.gov/articles/PMC4861060/

[ 4 ] Chelakkot, C., Ghim, J. & Ryu, S.H. Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 2018. https://pmc.ncbi.nlm.nih.gov/articles/PMC10005347/
[ 5 ] Moonwiriyakit A, et al. Tight junctions: from molecules to gastrointestinal diseases. Tissue Barriers. 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10161963/

[ 6 ] Canani RB, et al. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011. 
 https://pmc.ncbi.nlm.nih.gov/articles/PMC3070119/

[ 7 ] Parada Venegas D, et al. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front Immunol. 2019. https://pmc.ncbi.nlm.nih.gov/articles/PMC6421268/

[ 8 ] Peng L, et al. Butyrate enhances the intestinal barrier by facilitating tight junction assembly. J Nutr. 2009. https://pmc.ncbi.nlm.nih.gov/articles/PMC2728689/

[ 9 ] Cani PD, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007. https://pubmed.ncbi.nlm.nih.gov/17456850/

[ 10 ] Clemente-Postigo M, et al. Metabolic endotoxemia promotes adipose dysfunction and Inflammation Am J Physiol Endocrinol Metab. 2019. https://journals.physiology.org/doi/full/10.1152/ajpendo.00277.2018

[ 11 ] Wu H, Ballantyne CM. Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020. https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.315896

[ 12 ] Wang L, et al. Positive Interventional Effect of Engineered Butyrate-Producing Bacteria on Metabolic Disorders and Intestinal Flora Disruption in Obese Mice. Microbiol Spectr 2022. https://doi.org/10.1128/spectrum.01147-21

[ 13 ] Chilton PM, et al. Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role. Gut Microbes. 2024.  https://pmc.ncbi.nlm.nih.gov/articles/PMC11346541/

[ 14 ] Santoro A, et al. Gut microbiota changes in the extreme decades of human life. Cell Mol Life Sci. 2018. https://pmc.ncbi.nlm.nih.gov/articles/PMC5752746/

[ 15 ] Kirschner SK, et al. Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation. Am J Clin Nutr. 2025 https://pubmed.ncbi.nlm.nih.gov/40274191/

[ 16 ] Shepherd SJ, et al. Dietary triggers of abdominal symptoms in IBS patients. Clin Gastroenterol Hepatol. 2008.
 https://pubmed.ncbi.nlm.nih.gov/18456565/

[ 17 ] Staudacher HM, Whelan K. The low FODMAP diet: recent advances and efficacy in IBS. Gut. 2017. https://pubmed.ncbi.nlm.nih.gov/28592442/

[ 18 ] Hewagalamulage SD, et al. Stress, cortisol, and obesity. Domest Anim Endocrinol. 2016.
 https://pubmed.ncbi.nlm.nih.gov/27345309/

[ 19 ] Dodoo CC, et al. Targeted delivery of probiotics to enhance gastrointestinal stability. Int J Pharm. 2017. https://discovery.ucl.ac.uk/id/eprint/1568933/1/Gaisford_IJP%20probiotics%20R1.pdf

[ 20 ] Hewagalamulage SD, et al. Stress, cortisol, and obesity. Domest Anim Endocrinol. 2016.
 https://pubmed.ncbi.nlm.nih.gov/27345309/

[ 21 ] Drapeau V, et al. Is visceral obesity a physiological adaptation to stress? Panminerva Med. 2003. https://pubmed.ncbi.nlm.nih.gov/14618117/

[ 22 ] Konturek PC, et al. Stress and the gut: pathophysiology, clinical consequences. J Physiol Pharmacol. 2011..
 https://pubmed.ncbi.nlm.nih.gov/22314561/

[ 23 ] Igudesman D, et al. Laxative Abuse Is Associated With a Depleted Gut Microbial Community. Psychosom Med. 2023.
 https://pubmed.ncbi.nlm.nih.gov/37363967/
[ 24 ] Cresci GA, et. al. Tributyrin supplementation protects mice from acute gut injury. Alcohol Clin Exp Res. 2014. https://pmc.ncbi.nlm.nih.gov/articles/PMC4185400/

[ 25 ] Zhen H, et al. Fructooligosaccharides for Relieving Functional Constipation: Systematic Review and Meta-Analysis. Foods. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11675838/

[ 26 ] Ouwehand AC, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting. Vaccine. 2014. https://pubmed.ncbi.nlm.nih.gov/24291194/

[ 27 ] IFF Health Sciences. HOWARU® Restore: Clinically Documentation 2021. https://healthsciences.iff.com/fileadmin/user_upload/Editor/Documents/HOWARU_Restore_-_Handout_-_IFF_Health.pdf

[ 28 ] Ianiro G,et al. Digestive Enzyme Supplementation in Gastrointestinal Diseases. Curr Drug Metab. 2016. https://pubmed.ncbi.nlm.nih.gov/26806042/

[ 29 ] Martin-Biggers J. A Multi-Digestive Enzyme Supplement Reduces Bloating in Healthy Adults. Nutrition and Dietary Supplements. 2024. https://www.dovepress.com/a-multi-digestive-enzyme-and-herbal-dietary-supplement-reduces-bloatin-peer-reviewed-fulltext-article-NDS

[ 30 ] Mitsou EK, et. al. Effects of Β-Glucans Edible Mushrooms on Aging Gut Microbiota. Molecules. 2020. https://pmc.ncbi.nlm.nih.gov/articles/PMC7355846/

[ 31 ] Edo GI, et al. A critical review on β-glucans impact on gut microbiota and human health. Food Biosci. 2025. https://www.sciencedirect.com/science/article/pii/S2950194625001621

[ 32 ] Duysburgh C, et al. Tributyrin (CoreBiome®) enhances butyrate levels and modulates gut health. Front Nutr. 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC12746503/