The world's only fermented tributyrin that releases butyrate directly in your colon
DIGESTIVE & GUT REPAIR PROBIOTICS
Why Your Constipation Keeps Coming Back No Matter What You Try — And How to Break the Cycle In 2 Days[1]
It’s called “The CONSTIPATION TRAP”: 95% of the U.S. population is deficient in ONE critical compound.[2] Without it, every time you get backed up, your gut makes it worse. Here’s how to escape for good.
- Poop every morning without straining*
- Feel confident in fitted clothes*
- Enjoy meals without fear*
- Stop planning your day around bathrooms*
- Go to bed feeling light*
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- See initial results in 2 weeks*
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3-Month Supply
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$49.49per bottle
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- 90 servings ($1.64/day)
- Establish daily regularity
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$89.99
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- Establish daily regularity
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6-Month Supply
Full gut repair cycle
$44.99per bottle
$89.99
- 180 servings ($1.49/day)
- Complete digestive freedom
- 6 bottles delivered
Best Value Save 35%
6-Month Supply
Full gut repair cycle
$58.49per bottle
$89.99
- 180 servings ($1.94/day)
- Complete digestive freedom
- 6 bottles delivered
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Join 35,000+ Bioma Probiotics Customers Who Went From Stressed & Anxious To Calm & In Control
I’ve tried EVERYTHING… fiber, probiotics, laxatives and nothing worked long term.
Bioma gave me relief in 3 days and I’ve been regular ever since… I actually look forward to my mornings now!
No more painful straining. No more planning my route and day around where the next clean bathroom is… The first thing that actually worked for me. Thank you!!!
I was skeptical about the 48-72 hours claim but all I can say is WOW.. I mean by the end of day 2 I felt lighter, less bloated, and actually pooped without forcing it. My pants fit better too...
Why Everything You Eat Seems to Make Your Constipation Worse
If you're constipated more than 2-3 days a week, the issue isn't your fiber or water intake. It's your damaged gut barrier.
Gut barrier is a protective lining. It has a surface area of over 300 square feet[9]. But it's only one cell thick, despite being ultra-thin, it's very strong.
When it's healthy:
- Nutrients get absorbed efficiently
- Harmful toxins stay blocked out
- Good bacteria thrive
- Food moves smoothly through your digestive tract
- You have regular, easy bowel movements
But here's where things go wrong...
To remain healthy and strong your gut needs a compound called butyrate to function.[10] [11]
You can think of butyrate as "superfuel" that seals your damaged gut lining and powers the muscle contractions to move poop effortlessly.
Your gut barrier is only ONE CELL THICK
It needs butyrate as fuel to maintain tight junctions and protect you from inflammation.[12]
Without butyrate, tight junctions break down
Inflammation floods in, triggering the immune system and slowing gut motility
This creates the Constipation Trap
Constipation reduces butyrate production, causing more constipation. The cycle perpetuates itself.
So here’s the real problem.
95% of Americans are butyrate-deficient.
And it gets even worse with age, after 40, research shows butyrate production declines significantly with age, by up to 50% in older adults[13] [14], which is why constipation gets progressively worse...
This creates a vicious cycle, what we call The “CONSTIPATION TRAP”:
Constipation → Less gut movement → Less bacterial fermentation → Less butyrate production → Weaker gut barrier → More inflammation → Slower digestion → Constipation
… and the cycle repeats.
You're trapped in the constipation trap where constipation causes more constipation.
The Constipation Trap
So even if you try to fix this with taking generic probiotics, adding more fiber to your diet, or drinking more water, the truth is that these “solutions” will only mask your symptoms, and that’s why constipation often comes back with a vengeance.
Leaky gut allows toxins into your bloodstream, triggering inflammation that slows gut motility. Slower motility means less butyrate production, making the leak worse.
The result is that 95% of Americans can't produce enough butyrate to maintain a healthy gut barrier.
Stomach acid destroys 95% of probiotic bacteria.[15] That's why Bioma uses delayed-release capsules that protect the bacteria until they reach your colon alive.
Butyrate. It's your gut's primary fuel source. Multiple studies show production declines significantly with age[13] [14], which is why constipation gets worse over time. CoreBiome® replaces this missing fuel.
Stress activates your sympathetic nervous system, which shuts down digestion. Chronic stress creates chronic constipation.[16] [17] Fixing your gut barrier reduces this stress response.
Why Traditional Probiotics, Fiber and Laxatives Fail
If you have done all you've been told to do with no permanent or any success at all... It's not your fault.
Here's why...
Without the right gut bacteria and butyrate, fiber just ferments and causes MORE bloating[18] [19]
WHAT THEY SAY:
"Just eat more fiber and you'll poop more often."
THE REALITY:
"Without the right gut bacteria to ferment fiber, you just get MORE constipated and bloated. It's like trying to start a fire with wet wood."
95% die in stomach acid before reaching your colon[15]. The few survivors can’t thrive in a damaged inflamed gut environment.
WHAT THEY SAY:
"Add good bacteria and your gut will be healthy."
THE REALITY:
"95% die in stomach acid before reaching your colon. The survivors starve because your gut is too inflamed to produce the butyrate they need to thrive."
Force unnatural contractions create dependency, and damage your gut lining over time.[20] [21] You end up worse than when you started.
WHAT THEY SAY:
"“Force it out and you’ll feel better"
THE REALITY:
"Creates dependency, weakens natural muscle contractions, and strips away protective mucus. You end up WORSE than when you started."
And none of these address the root cause:
Repairing Your Gut Barrier
Not addressing your damaged gut barrier may lead to "leaky gut". A syndrome where toxins start to leak into your bloodstream and trigger inflammation that slows down your digestive system even more[22], creating what we call the "CONSTIPATION TRAP" amongst other health issues.
Healthy Gut
- Produces butyrate naturally
- Gut motility normal
- Regular bowel movements
Leaky Gut
- Butyrate deficient (95% of Americans)[2]
- Inflammation slows everything down
- Constipation cycle begins
So if traditional solutions don't work... what does?
You need to repair the foundation of your gut first.
Introducing The Revolutionary 5-Step Gut Repair System That Breaks The Constipation Trap
Unlike traditional probiotics, BIOMA's Digestive & Gut Repair takes care of your gut barrier first, then rebuilds your microbiome
Traditional Approach
- Add probiotics to damaged gut
- Most die in stomach acid[15]
- Temporary relief (maybe)
- Single mechanism
Bioma's Approach
- Seal gut barrier FIRST
- Delayed-release capsules
- Lasting transformation
- 5-in-1 system
Most supplements try to add probiotics or fiber to a broken gut system. But it's like trying to fill up a bucket that has holes in it.
BIOMA Digestive & Gut Repair Probiotics work differently.
It contains CoreBiome® Tributyrin, the world's first and only clinically-proven postbiotic that delivers butyrate directly to your colon to seal your gut barrier in as little as 2 days.
Once your gut is sealed, everything else starts to work again.
That's why Bioma includes prebiotics to feed good bacteria, probiotics that actually survive your stomach acid (due to delayed-release capsules), digestive enzymes, and immune support, all working in sequence.
Step 1
Seal Your Gut Barrier
CoreBiome® Tributyrin (150mg)
POSTBIOTIC
What Is It:
Why It Matters for Constipation:
Strengthens tight junctions, reduces inflammation, nourishes intestinal cells.
Improved gut barrier in just 2 days[1]
The Result:
Your gut can function normally again
Step 2
Feed Your Good Bacteria
FOS + Acacia Fiber (250mg)
Prebiotics
What Is It:
Food for beneficial bacteria like Bifidobacteria and Lactobacilli
Why It Matters for Constipation:
Increases beneficial bacteria, softens stool, stimulates peristalsis.
Research-backed:
Significantly increases Bifidobacteria and improves bowel frequency in clinical studies[4] [24]
The Result:
Your gut produces its own butyrate
Step 3
Replenish Beneficial Strains
Howaru Restore® (10 Billion CFU)
Probiotics
What Is It:
4 clinically-studied strains in delayed-release capsules
Strains included:
- Lactobacillus acidophilus NCFM®
- Lacticaseibacillus paracasei Lpc-37®
- Bifidobacterium lactis Bl-07®
- Bifidobacterium lactis Bl-04®
Why It Matters for Constipation:
Restores microbial balance, reduces bloating, shortens transit time.
Research-backed:
52% faster recovery from digestive distress.[25]
The Result:
Your gut flora works in harmony
Step 4
Break Down Food Efficiently
Bromelain + Papain (100mg each)
Digestive Enzymes
What Is It:
Proteolytic enzymes from pineapple and papaya
Why It Matters for Constipation:
Prevents food fermentation, reduces bloating, minimizes backup
Research-backed:
Digestive enzyme combinations clinically shown to reduce bloating and improve digestive comfort.[5] [7]
The Result:
Food moves smoothly through your system
Step 5
Strenghthen Immune Defense
Hōlistiq™ Mushroom Beta-Glucans (100mg)
Immune Support
What Is It:
6 organic medicinal mushrooms
Why It Matters for Constipation:
Feeds bacteria, reduces inflammation, strengthens gut-immune axis
Research-backed:
Beta-glucans from medicinal mushrooms activate immune cells and modulate inflammatory response[26] “[27]
The Result:
Your gut becomes more resilient
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What Happens When You Fix Your Gut The Scientifically Proven Way
Highest Standards of Quality, Powerhouse Ingredients, All Backed By Science
Initial Relief
Days 1-3 (48-72 Hours)
What's happening: Gut barrier repair begins, inflammation decreases, motility improves
What you'll notice:
- Less bloating after meals
- Reduced cramping
- Easier bowel movements starting
Regularity Restored
Weeks 1-2
What's happening: Good bacteria multiply, probiotics colonize, enzymes optimize digestion
What you'll notice:
- Consistent daily bowel movements
- No more straining or forcing
- Feel lighter and more energized
Full System Reset
Months 1-2
What's happening: Gut barrier fully repaired, microbiome rebalanced, natural butyrate production restored
What you'll notice:
- Complete regularity (no surprises)
- Clothes fit noticeably better
- Eat wider variety of foods
- Better mood and sleep quality
- Zero bathroom anxiety
Deep Optimization
Months 3-4
What's happening: Microbiome diversity peaks, immune strengthening, peak digestive efficiency, inflammation markers drop significantly
What you'll notice:
- Zero bloating, even after big meals
- Better stress resilience
- Clearer, more radiant skin
- Fewer food sensitivities
- Feel 'bulletproof' digestively
Peak Performance & Protection
Months 5-6+
What's happening: Self-sustaining microbiome, lasting gut barrier strength, metabolic health improvements, anti-aging benefits from butyrate, peak immune function
What you'll notice:
- Effortless digestion is your new normal
- Sustained weight management
- Enhanced mental clarity and focus
- Overall vitality boost
- Fewer sick days
- Forgot what constipation feels like
- Friends notice you look healthier
Why Choose a 6-Month Supply?
Why Choose a 6-Month Supply?
Months 1-2
Fix the problem
Months 3-4
Optimize system
Months 5-6
Lock in transformation
"This is more than just a supplement, it's a lifestyle change."
Choose Your BIOMA Package And Put An End To The Constipation Trap
Free Shipping On All Orders
Cancel Anytime
100% Money-Back Guarantee
Try It Out SAVE 40%
1-Month Supply
Perfect for trying out
$53.99per bottle
$89.99
- 30 servings ($1.79/day)
- See initial results in 2 weeks*
- 1 bottle delivered
Try It Out Save 20%
1-Month Supply
Perfect for trying out
$71.99per bottle
$89.99
- 30 servings ($2.39/day)
- See initial results in 2 weeks*
- 1 bottle delivered
Most Popular SAVE 45%
3-Month Supply
Build healthy habits
$49.49per bottle
$89.99
- 90 servings ($1.64/day)
- Establish daily regularity
- 3 bottles delivered
Most Popular Save 30%
3-Month Supply
Build healthy habits
$62.99per bottle
$89.99
- 90 servings ($2.09/day)
- Establish daily regularity
- 3 bottles delivered
Best Value SAVE 50%
6-Month Supply
Full gut repair cycle
$44.99per bottle
$89.99
- 180 servings ($1.49/day)
- Complete digestive freedom
- 6 bottles delivered
Best Value Save 35%
6-Month Supply
Full gut repair cycle
$58.49per bottle
$89.99
- 180 servings ($1.94/day)
- Complete digestive freedom
- 6 bottles delivered
Plans renews automatically till cancelled
Third-Party Tested
Secure Checkout
Gluten-Free | Vegan
Organic Mushrooms
FDA & GMP Certified Facilities
Delayed-Release Capsules
Dark Glass Bottles for Product Quality
100% Natural & Non-GMO
Manufactured in USA
100% Money-Back Guarantee
We’re so confident BIOMA Digestive and Gut Repair Probiotics will transform your digestive health and end constipation trap, that we offer a complete money-back guarantee.
If you don’t see meaningful improvement in your constipation within 14 days, simply contact us for a full refund. No questions asked.
100% Money-Back Guarantee
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Cancel Anytime
Our Customers Talk About Bioma
What's Inside Bioma's Digestive & Gut Repair Probiotics
Highest Standards of Quality, Powerhouse Ingredients, All Backed By Science
Manufacturing Excellence
- FDA & GMP Certified Facilities
- Delayed-Release Capsules
- Cold-Chain Processing
- Strict Quality Controls
Quality Testing
- Third-Party Lab Tested
- Certificate of Analysis
- Purity & Potency Verified
- Stability Guaranteed
Clean Formula
- 100% Vegan & Non-GMO
- Gluten & Allergen Free
- No Artificial Additives
- No Fillers or Preservatives
- 100% Money-Back Guarantee
- Free Shipping
- Cancel Anytime
Imagine Waking Up Tomorrow Feeling Light, Regular, and Free
This could be your new reality in just 48 hours
No more..
- Painful straining on the toilet
- Constant bloating and discomfort
- Anxiety about bathroom breaks
- Avoiding certain foods or social events
- Feeling backed up and heavy all day
- Trying supplement after supplement
- Planning your day around finding bathrooms
- Feeling uncomfortable in your own skin
WITH BIOMA DIGESTIVE & GUT REPAIR PROBIOTICS
Instead, you'll experience...
- Effortless morning bowel movements
- A flat, comfortable stomach all day
- Confidence to eat the foods you love
- Freedom to travel and socialize worry-free
- Clothes that fit better and feel comfortable
- More energy and better mood
- Peaceful nights without digestive distress
- True freedom from digestive anxiety
The choice is yours. Stay trapped in the cycle, or break free in 48 hours.
Join thousands who've already broken free from the constipation trap
- Zero Risk - 100% Satisfaction Guarantee
- Free Shipping
- Cancel Anytime
Frequently Asked Questions
Get answers to common questions about BIOMA
Most customers notice less bloating and easier bowel movements within the first 48-72 hours. Full gut repair and consistent regularity typically occurs within 2-4 weeks as your gut barrier heals and microbiome rebalances.
Yes. Bioma is formulated with natural, clinically-tested ingredients and is designed for daily, long-term use. It's manufactured in FDA-registered, GMP-certified facilities and is third-party tested for purity and potency. Unlike laxatives, Bioma doesn't create dependency.
Traditional probiotics only add bacteria, most of which die in stomach acid. Bioma uses delayed-release capsules AND repairs your gut barrier FIRST with CoreBiome® postbiotic. This creates a healthy environment where probiotics can actually survive and thrive.
Many of our customers have IBS-C (IBS with constipation), chronic constipation, or other digestive issues. Bioma addresses the root cause, gut barrier dysfunction, which underlies many digestive problems. However, we recommend consulting your doctor if you have severe conditions
We offer a 100% money-back guarantee. If you don't see meaningful improvement within 14 days, simply contact our customer service team for a full refund. No questions asked. We take all the risk so you don't have to.
100% Money-Back Guarantee
Free Shipping
Cancel Anytime
References
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1
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- Cresci GA, Bush K, Nagy LE. Tributyrin Supplementation Protects Mice from Acute Ethanol-Induced Gut Injury. Alcohol Clin Exp Res. 2014 Jun;38(6):1489-1501.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4185400/
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- Quagliani D, Felt-Gunderson P. Closing America's Fiber Intake Gap. Am J Lifestyle Med. 2017 Jan-Feb;11(1):80-85.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6124841/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC5670282/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC11675838/
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https://www.dovepress.com/a-multi-digestive-enzyme-and-herbal-dietary-supplement-reduces-bloatin-peer-reviewed-fulltext-article-NDS
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- Dimidi E, Christodoulides S, Scott SM, Whelan K. Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation. Adv Nutr. 2017 May 15;8(3):484-494.
https://pubmed.ncbi.nlm.nih.gov/28507013/
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- Ullah H, Di Minno A, Piccinocchi R, et al. Efficacy of digestive enzyme supplementation in functional dyspepsia: A monocentric, randomized, double-blind, placebo-controlled, clinical trial. Biomed Pharmacother. 2023 Dec 31;169:115858.
https://pubmed.ncbi.nlm.nih.gov/37976892/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10806726/
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https://pubmed.ncbi.nlm.nih.gov/24694282/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3070119/
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- Parada Venegas D, De la Fuente MK, Landskron G, et al. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front Immunol. 2019 Mar 11;10:277.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6421268/
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- Peng L, Li ZR, Green RS, Holzman IR, Lin J. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr. 2009 Sep;139(9):1619-25.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2728689/
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- Kirschner SK, Engelen MPKJ, Haas P, et al. Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial. Am J Clin Nutr. 2025 Jun;121(6):1224-1235.
https://pubmed.ncbi.nlm.nih.gov/40274191/
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- Dodoo CC, Wang J, Basit AW, Stapleton P, Gaisford S. Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation. Int J Pharm. 2017 Jul 15;530(1-2):224-229.
https://discovery.ucl.ac.uk/id/eprint/1568933/1/Gaisford_IJP%20probiotics%20R1.pdf
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- Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol. 2011 Dec;62(6):591-9.
https://pubmed.ncbi.nlm.nih.gov/22314561/
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- Fukudo S, Kanazawa M. Gene, environment, and brain-gut interactions in irritable bowel syndrome. J Gastroenterol Hepatol. 2011 Apr;26 Suppl 3:110-5.
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- Shepherd SJ, Parker FC, Muir JG, Gibson PR. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol. 2008 Jul;6(7):765-71.
https://pubmed.ncbi.nlm.nih.gov/18456565/
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- Staudacher HM, Whelan K. The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS. Gut. 2017 Aug;66(8):1517-1527.
https://pubmed.ncbi.nlm.nih.gov/28592442/
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- Muller-Lissner S. Adverse effects of laxatives: fact and fiction. Pharmacology. 1993 Oct;47 Suppl 1:138-45.
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- Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum. 2001 Aug;44(8):1201-9.
https://pubmed.ncbi.nlm.nih.gov/11535863/
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- Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019 Aug;68(8):1516-1526.
https://pubmed.ncbi.nlm.nih.gov/31076401/
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- Fasano A. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol. 2012 Feb;42(1):71-8.
https://pubmed.ncbi.nlm.nih.gov/22109896/
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- Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J Gastroenterol. 2011 Sep;46(9):1057-64.
https://pubmed.ncbi.nlm.nih.gov/21663486/
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- Ouwehand AC, DongLian C, Weiss G, Ouwehand E, Motiani P, Lundell J. Probiotics reduce symptoms of antibiotic use in a hospital setting: A randomized dose response study. Vaccine. 2014 Jan 3;32(4):458-63.
https://pubmed.ncbi.nlm.nih.gov/24269618/
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- Vetvicka V, Vannucci L, Sima P. The effects of β-glucan on pig growth and immunity. Open Biochem J. 2014 Oct 31;8:89-93.
https://pubmed.ncbi.nlm.nih.gov/25410625/
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- Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009 Jun 10;2:25.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2704234/
