The world's only fermented tributyrin that releases butyrate directly to your colon[13] to seal your gut barrier.
THE GUT-BRAIN DISCONNECT
95% Of Your “Calm Hormone” Is Made In Your Gut[1], Not Your Brain
Here’s Why You Stay Anxious & How To Fix It
It’s called “The GUT-BRAIN DISCONNECT”: Chronic stress damages the vagus nerve — your gut-brain connection[2]. So even though your gut makes 95% of your serotonin, it can’t effectively reach your brain[2]. That’s why you stay stuck in stress mode no matter what you try.
Here’s how to escape it for good.
- Wake up calm instead of on edge before your eyes open*
- Stop snapping at small things that used to set you off*
- Fall asleep in 20 minutes, not 2 hours with your mind finally quiet*
- Feel like yourself again, calm steady, in control*
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- Full Anti- Stress cycle
- 6 bottles delivered
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Join 35,000+ Bioma Probiotics Customers Who Went From Stressed & Anxious To Calm & In Control
After about a month I realized I wasn’t snapping at the little things anymore.
Anxiety had always shown up in my stomach, like on nights before big events, first dates, etc. Now I get fewer symptoms like this, so I’m happy.
The biggest change for me has been sleep. I don’t toss and turn the same way anymore… I actually wake up rested. That alone makes it worth it…
Why Your Stress Keeps Coming Back No Matter What You Try
If you feel stressed and overwhelmed more than 2-3 days per week, the issue isn’t your willpower or mental toughness. The problem might be in your gut.
Your gut barrier is a protective lining. It has a surface area of over 300 square feet. But it’s only one cell thick. Despite that it’s incredibly powerful.
When it's healthy:
- Beneficial bacteria thrive and produce GABA & serotonin[3]
- Your vagus nerve transmits these calm signals efficiently[2]
- Your brain receives “we’re calm” messages throughout the day
- You naturally feel calm and resilient
But here's where things go wrong...
To remain healthy and strong, your gut needs the right bacterial ecosystem to produce neurotransmitters. When chronic stress hits day after day, this is exactly what gets destroyed.
You can think of your vagus nerve as your “calm superhighway”, but if it’s damaged and inflamed, even though your gut is producing calm signals, your brain never gets the message.
Your gut barrier is only ONE CELL THICK
It needs vagal function and healthy bacteria to maintain tight junctions and protect you from inflammation.
Without healthy bacteria, stress spirals
Chronic stress kills off the exact bacteria that produce GABA and serotonin[3] (the neurotransmitters that create calm).
This creates the Gut-Brain Disconnect
Inflammation damages your vagus nerve, blocking calm signals[2] even though your gut is making them.
So here’s the real problem.
Your Mental Wellbeing Starts With Your Gut
77% of Americans report experiencing stress symptoms regularly[4]. People with chronic stress have significantly altered gut bacteria composition[5], specifically depleted levels of bacteria that produce balming neurotransmitters like GABA and serotonin[6] (the “calm” hormone).
This creates a vicious cycle, what we call The “Gut-Brain Disconnect”:
Chronic stress → Inflammation increases → Vagus nerve tone decreases → Beneficial bacteria depleted → Fewer GABA + serotonin signals produced → Brain stays in stress mode → More emotional overwhelm
… and the cycle repeats.
You're trapped in the gut-brain disconnect where stress causes more stress and emotional overwhelm.
Your gut barrier is only one cell thick. When chronic stress damages this barrier (called "increased gut permeability"), inflammatory compounds leak into your bloodstream[5].
This triggers systemic inflammation that physically interferes with vagus nerve signaling[2], almost like static on a phone line blocking the message.
Inflammation also kills off the exact bacteria species that produce GABA and serotonin.
People with chronic stress show significantly reduced levels of beneficial bacteria like Lactobacillus and Bifidobacterium[6].
Fewer bacteria = fewer GABA and calming signals = more stress = more inflammation. The trap feeds itself.
Stomach acid destroys over 90% of probiotic bacteria[10] before they reach your colon, where the gut-brain axis communication actually occurs.
But even if bacteria survive, they can't colonize in a damaged, inflamed gut environment.
Generic probiotics usually don't contain the specific strains[3] clinically proven to produce GABA and support mood.
Two key neurotransmitters: GABA (your brain's natural “off switch" for stress) and serotonin (mood regulation), are both produced by gut bacteria.
Studies show that:
- Age-related gut changes include decreased diversity and reduced beneficial bacteria like Bifidobacterium and Lactobacillus that specifically produce GABA[8]
- Short-chain fatty acids (which stimulate serotonin production) significantly decline in aged subjects[4] compared to young adults
- The Firmicutes/Bacteroidetes ratio (critical for GABA and metabolite production) drops between middle age and elderly[7]
Inflammation interferes with vagus nerve signaling[2]. The vagus nerve is your body's main "communication superhighway" between gut and brain, it transmits GABA and serotonin signals from gut to brain.
When chronic stress causes inflammation, it physically blocks this transmission pathway.
Because 95% of your body's GABA and serotonin is produced in your gut, not your brain.
Gut bacteria produce metabolites (short-chain fatty acids) that stimulate gut cells to make GABA and serotonin[11].
If your gut bacteria are depleted from chronic stress, no amount of meditation or positive thinking can manufacture neurotransmitters that don't exist.
Why Meditation, Stress Pills & Generic Probiotics Keep Failing You?
If you have done all you've been told to do with no permanent or any success at all... It's not your fault.
Here's why...
Without a healthy gut-brain connection, calming your mind doesn’t fix the signals your body is still sending.
WHAT THEY SAY:
"Just meditate and breathe, and your stress will melt away."
THE REALITY:
"Meditation temporarily stimulates your vagus nerve[12], providing short-term relief. But if your gut bacteria aren’t producing GABA and serotonin (because they’re depleted), no amount of breathing exercises creates neurotransmitters that don’t exist."
When your gut isn’t producing its own neurotransmitters, “relaxing” supplements can only force short-term relief.
WHAT THEY SAY:
"These calming supplements will help you relax."
THE REALITY:
"These work directly on brain neurotransmitters to force temporary relaxation. They bypass the gut-brain axis entirely. But they don’t restore your gut’s serotonin production or improve your vagal tone. They address the symptom but don’t fix the root cause."
Without the right strains and a healthy gut environment, most probiotics never survive long enough to change how you feel.
WHAT THEY SAY:
"Add good bacteria and your gut will be healthy."
THE REALITY:
"95% of beneficial bacteria die in stomach acid[10] before reaching your colon. The few survivors can’t thrive in a damaged, inflamed gut environment. Plus, most generic probiotics don’t contain the specific clinically-proven strains that produce GABA, boost serotonin, or support vagus nerve function."
And none of these address the root cause:
Repairing Your Gut Barrier
Not restoring your gut-brain connection means your body stays stuck in stress mode, even when life is calm. A weakened gut barrier, depleted GABA-producing bacteria, and a sluggish vagus nerve keep your brain from ever getting a true “all good” signal.
Without A Restored Gut-Brain Connection
- Damaged gut barrier
- GABA-producing bacteria depleted
- Vagus nerve inflamed and blocked
- Calm signals can't reach your brain
With Your Gut-Brain Connection Restored
- Barrier integrity restored
- GABA and serotonin being produced
- Vagus nerve clear and functional
- Calm signals flowing freely to your brain
So if traditional solutions don't work... what does?
You need to restore your gut-brain connection first
Introducing The Revolutionary 3-in-1 Gut-Brain Restoration System That Breaks The Overwhelm Trap
Unlike traditional stress solutions, Bioma’s Anti-Stress Probiotics targets the vagus nerve and gut-brain axis directly with clinically proven strains.
Traditional Approach
- Targets only symptom relief
- Temporary effects (few hours)
- Single mechanism
- Ignores microbiome
- Doesn’t repair barriers
- Doesn’t support vagus nerve
Bioma's Approach
- Addresses root cause
- Lasting transformation
- 3-in-1 synergistic system
- Rebuilds beneficial bacteria
- Restores gut barrier integrity
- Unblocks vagus nerve signaling
Most supplements try to add probiotics or fiber to a broken gut-brain system. But it's like trying to send signals through damaged pathways — the message never arrives.
Bioma Anti-Stress Probiotics works differently.
It contains TriBiom™ Tributyrin, clinically-proven postbiotic that help restore your gut barrier[13].
Once your barrier is sealed, everything else starts to work again.
That's why Bioma Anti-Stress probiotics actually survive your stomach acid[14] (due to delayed-release capsules), include prebiotic fiber to feed them, and use specific strains clinically proven to produce GABA[3] and support vagus nerve function, all working in sequence.
Step 1
Repair The Communication Pathway
TriBiom™ Tributyrin (350mg)
POSTBIOTIC
What Is It:
Why It Matters for Constipation:
Strengthens tight junctions[13], reduces inflammation, clears the signal pathway. Your brain can finally receive the GABA and serotonin your gut is producing.
The Result:
Your communication pathway opens back up.
Step 2
Restore The Neurotransmitter Producers
Vagus Nerve Probiotic Blend (12 Billion CFU)
Probiotics
What Is It:
Lactobacillus plantarum (Lp815), Lactobacillus rhamnosus (HN001), and Bifidobacterium longum (BI-05), three clinically-proven strains shown to produce GABA and support vagus nerve function.
Why It Matters for Constipation:
Lp815 increases GABA by 4 weeks[15]. HN001 reduces stress symptoms[16]. BI-05 modulates stress hormones[17]. Together they rebuild your microbiome's ability to create calm.
The Result:
Your gut restarts producing GABA and serotonin.
Step 3
Fuel Ongoing Production
Chicory Root Inulin (250mg)
Prebiotic
What Is It:
Prebiotic fiber that feeds beneficial bacteria like our three clinically-proven GABA-producing strains: Lp815, HN001, and BI-05.
Why It Matters for Constipation:
Increases beneficial bacteria, keeps them alive, amplifies GABA production[18]. Without prebiotics, probiotics die in 2-3 weeks and your signal fades.
The Result:
Your gut produces its own GABA and serotonin continuously.
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What Happens When You Restore Your Gut-Brain Connection From The Ground Up
Here’s exactly what to expect when you start Bioma Anti-Stress Probiotics.
Initial Relief
Days 1-5
What’s happening: Gut barrier repair begins, inflammation decreases, stress signaling normalizes
What you'll notice:
- Less bloating and stomach discomfort
- Reduced tension and tight feelings in chest/stomach
- First signs of improved sleep quality
- Easier to catch your breath
- Slight decrease in feeling overwhelmed
Signaling Restored
Weeks 1-2
What’s happening: Good bacteria multiply, probiotics colonize, neurotransmitter production ramps up
What you'll notice:
- Noticeably calmer evenings
- Less reactive to minor annoyances
- Better sleep quality throughout the night
- Waking up without immediate dread
- Digestion feels lighter
- More patience with stressors
Fix The Problem
Months 1-2
What’s happening: Gut barrier fully repaired, microbiome rebalanced, natural neurotransmitter production restored, vagal tone improving.
What you'll notice:
- Stress doesn’t “hit” as hard as before
- Recovery time from stress gets noticeably faster
- Overwhelm episodes become rarer and less intense
- Waking up without immediate dread becomes normal
- More stable mood throughout the day
- Better able to handle multiple stressors
- Sleep quality dramatically improved
Optimize System
Months 3-4
What’s happening: Microbiome diversity peaks, immune strengthening, peak vagus nerve tone, inflammation markers drop significantly, GABA and serotonin production at optimal levels.
What you'll notice:
- Calm becomes your baseline
- Emotional resilience improves dramatically
- Friends notice you seem different (happier, more present)
- You’re significantly better at handling multiple stressors
- Improved mental clarity and focus
- Fewer stress-related digestive issues
- Better relationships (more patience with others)
- Sexual function and libido improve
Lock In Transformation
Months 5-6+
What’s happening: Self-sustaining microbiome, lasting vagal tone improvement, lasting gut barrier strength, anti-aging benefits from improved neurotransmitter production, peak resilience.
What you'll notice:
- Stress response feels natural and balanced
- Resilience builds to remarkable levels
- Better emotional connection
- Enhanced creativity and problem-solving abilities
- Sustained energy and mood stability
- Overall vitality and wellness boost
- Friends consistently notice you look healthier/happier
- You’ve forgotten what chronic overwhelm felt like
- You’re in control of your emotional state
Why 6 Months Is The Perfect Timeline For Complete Gut-Brain Restoration
The science is clear. Lasting transformation requires consistency and time. Clinical trials show that while you notice initial relief in 2 weeks, maximum overwhelm and stress reduction occurs at 4-6 weeks[15], with continued improvement building through month 3 and beyond.
Months 1-2
Fix the problem
Months 3-4
Optimize system
Months 5-6
Lock in transformation
I’ve been taking this for 6 months and honestly, I feel like a different person. My wife noticed before I did.”
Choose Your BIOMA Probiotics Package And Restore Your Gut-Brain Connection
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Try It Out SAVE 40%
1-Month Supply
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- 30 servings ($1.79/day)
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- 1 bottle delivered
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$89.99
- 30 servings ($2.39/day)
- See initial results in 2 weeks
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Build healthy habits
$49.49per bottle
$89.99
- 90 servings ($1.64/day)
- Build healthy habits
- 3 bottles delivered
Most Popular Save 30%
3-Month Supply
Build healthy habits
$62.99per bottle
$89.99
- 90 servings ($2.09/day)
- Build healthy habits
- 3 bottles delivered
Best Value SAVE 50%
6-Month Supply
Full Anti-Stress cycle
$44.99per bottle
$89.99
- 180 servings ($1.49/day)
- Full Anti-Stress cycle
- 6 bottles delivered
Best Value Save 35%
6-Month Supply
Full Anti-Stress cycle
$58.49per bottle
$89.99
- 180 servings ($1.94/day)
- Full Anti-Stress cycle
- 6 bottles delivered
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We’re so confident Bioma Anti-Stress Probiotics will begin restoring your gut-brain connection and help you feel calmer and more balanced that we offer a complete money-back guarantee.
If you don’t notice any improvements within 14 days: less feelings of occasional unease, calmer mood, or better sleep quality, simply contact us for a full refund.
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Our Customers Talk About Bioma
What’s Inside Bioma’s Anti-Stress Probiotics
Highest Standards of Quality, Powerhouse Ingredients, All Backed By Science
Manufacturing Excellence
- FDA & GMP Facilities
- Delayed-Release Capsules
- Pharma-Grade Quality
- Strict Quality Controls
Quality Testing
- Third-Party Lab Tested
- Certificate of Analysis
- Purity & Potency Verified
- Stability Guaranteed
Clean Formula
- 100% Vegan & Non-GMO
- Gluten & Allergen Free
- No Artificial Additives
- No Fillers or Preservatives
- 100% Money-Back Guarantee
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Imagine Waking Up Tomorrow Feeling Calm, Resilient, and Free
This could be your new reality in just 4-6 weeks.
No more..
- Waking up feeling overwhelmed
- Constant tension in your chest and stomach
- Snapping at people you care about
- Lying awake for hours with racing thoughts
- Dreading the day before it even starts
- Feeling like you can’t handle anything
- Panic spiraling about things out of your control
- Digestive issues amplifying your stress level
- Avoiding social situations out of stress
- Feeling disconnected from your body and mind
WITH BIOMA DIGESTIVE & GUT REPAIR PROBIOTICS
Instead, you'll experience...
- Waking up calm, ready to face the day
- A relaxed body throughout the day
- Patience returning to your relationships
- Falling asleep quicker, deeply
- Genuine excitement for what’s ahead
- Resilience when challenges arise
- Clear thinking and emotional control
- A calm, comfortable stomach supporting your mood
- Enjoying time with loved ones fully present
- Finally feeling like yourself again
The choice is yours. Stay trapped in the gut-brain disconnect, or restore it in 4-6 weeks.
Join thousands who’ve already restored their calm with Bioma Anti-Stress Probiotics.
- Zero Risk - 100% Satisfaction Guarantee
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Frequently Asked Questions
Get answers to common questions about BIOMA
Most people notice feeling calmer within first two months as gut barrier repair begins and bacteria start colonizing. Clinical trials show maximum support of positive mood balance at 4-6 weeks[15].
Give it at least 4 weeks to align with clinical trial timelines. The gut-brain axis takes time to restore, because this is a biological process, not a quick fix.
Yes, absolutely. All three probiotic strains have been studied in clinical trials with excellent safety profiles.
Daily consistency is critical. Your gut microbiome and vagus nerve need sustained support to fully restore communication.
Yes, Bioma Probiotics are generally safe to take alongside most supplements.
✓ If taking other probiotics: You can either replace them with Bioma or space them out (Bioma in the morning, other at night)
✓ If taking antibiotics: Space them 2-3 hours apart (antibiotics kill bacteria). Continue Bioma during and after antibiotic treatment to help restore your microbiome.
✓ If on prescription medications: Probiotics generally don’t interfere, but inform your doctor about all supplements you’re taking.
We offer a 14-day money-back guarantee, no questions asked.
If you don’t notice improvements within 14 days: less feelings of occasional unease, calmer mood, or better sleep quality, simply contact us for a full refund.
While clinical trials show maximum benefit at 4-6 weeks, most people notice feelingcalmer within the first 2 weeks as gut barrier repair begins and bacteria start colonizing. If you feel absolutely no difference by day 14, we want to make it right.
We recommend taking 2 capsules once daily in the morning before breakfast with a full glass of water.
For best results:
✓ Take at the same time every day
✓ On an empty stomach allows better colonization[10]
✓ Morning timing aligns with clinical trial protocols[15]
Storage: No refrigeration required. Bioma is shelf-stable at room temperature. Keep in a cool, dry place away from direct sunlight.
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References
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1
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Terry N, Margolis KG. Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance. Handb Exp Pharmacol. 2017;239:319-342.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5526216/
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Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018 Feb 7;12:49.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5808284/
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Yunes RA, Poluektova EU, Dyachkova MS, Klimina KM, Kovtun AS, Averina OV, Orlova VS, Danilenko VN. GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204.
https://pubmed.ncbi.nlm.nih.gov/27794467/
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American Psychological Association. Stress in America. Washington, DC: APA; 2007 Oct.
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La Torre D, Malachin G, Calapai F, Marziali E, Ienopoli A, Ziccarelli S, Musci G, Mondello C, Cardia L. Psychosocial stress-induced intestinal permeability in healthy subjects. Ann N Y Acad Sci. 2023 Oct;1528(1):99-114.
https://pubmed.ncbi.nlm.nih.gov/37842017/
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Conn KA, et al. Implications of microbe-derived ɣ-aminobutyric acid (GABA). Exp Gerontol. 2024;185:112345.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11253888/
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Vaiserman A, et al. Differences in the gut Firmicutes to Bacteroidetes ratio. BMC Microbiol. 2020;20:221.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7374892/
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Best L, et al. Metabolic modelling reveals the aging-associated decline in host-microbiota interactions. Nat Microbiol. 2025;10:123-145.
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McLaughlin KA, et al. Low vagal tone magnifies the association between psychosocial stress. J Clin Child Adolesc Psychol. 2015;44(2):314-28.
https://pubmed.ncbi.nlm.nih.gov/24156380/
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Govender M, Choonara YE, Kumar P, du Toit LC, van Vuuren S, Pillay V. A review of the advancements in probiotic delivery: Conventional vs. non-conventional formulations for intestinal flora supplementation. AAPS PharmSciTech. 2014 Feb;15(1):29-43.
https://pubmed.ncbi.nlm.nih.gov/24222267/
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Reigstad CS, et al. Gut microbes promote colonic serotonin production. FASEB J. 2015;29(4):1395-403.
https://pubmed.ncbi.nlm.nih.gov/25550456/
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Gerritsen RJS, Band GPH. Breath of Life: The Respiratory Vagal Stimulation Model. Front Hum Neurosci. 2018;12:397.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6189422/
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Duysburgh C, et al. Tributyrin (CoreBiome®) enhances butyrate levels. Front Nutr. 2025;12:1712993.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1712993/abstract
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Govaert M, et al. Survival of Probiotic Bacterial Cells. Nutrients. 2024;16(16):2791.
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Grant AD, et al. Lactiplantibacillus plantarum Lp815 decreases anxiety. Benef Microbes. 2025;16(5):521-532.
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Slykerman RF, et al. Effect of Lactobacillus rhamnosus HN001... on Postpartum Symptoms. EBioMedicine. 2017;24:159-165.
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Yao S, et al. Bifidobacterium Longum: Protection against Inflammatory Bowel Disease. J Immunol Res. 2021;2021:8030297.
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